By The Vascular Adventitia Transfected With E2f Decoy Oligonucleotide To Prevent Arterial Intimal Hyperplasia And Vascular Stenosis After Balloon Injury Research

Background: Gene therapy is a hot spot for study recently.There are many ways to carry it out and decoy strategy is one important part of it. Percutaneous transluminal coronary angioplasty(PTCA) is a method commonly used to treat patients with coronary heart disease.Although its clinical effect has been confirmed by many trials,restenosis after its administration has greatly restricted its application. With regard to this,a lot of researchers worked hard to find out and test the effects of different ways of preventing restenosis after PTCA,and the initial results were promising.But many problems following this revealed the fact that ideal feasible program is still lacking.Transcription factor(TF) E2F plays a pivotal role in cell cycle,so it is always chosen as a target TF during the decoy strategy.Different ways of carrying out the decoy strategy of E2F resulted in the similar phenomenon that transfection of E2F oligodeoxynucleotides(ODN) to local injured vascular endothelium could inhibit the vascular smooth muscle cell(VSMC) proliferation and neointimal hyperplasia to some extent,and effectively prevent the restenosis occurence,which were probably resulted from the suppression of the activation and...