Bone Marrow Mesenchymal Stem Cells Induced Differentiation And Transplantation In The Myocardium Experimental Study

BackgroundBone marrow mesenchymal stem cells(MSCs) are capable of self-replication and renewal. Under the certain condition they will differentiate into multiple lineages cells,including osteoblast, chondrocyte, adipocyte, neurocyte,muscle cells and so on.A big number of evidence have indicated that MSCs engrafted into the ischemic myocardium will regenerate the necrotic cardiomyocyte and endothelium ,even the Purkinje fiber,promote the perfusion through secretion of many growth factors,improve the heart function post-infarction.The clinical therapy based on the utilizing of MSCs pluropotential has become the new hope for numerous chronic heart failure patients.Many species MSCs' differentiation into cardiomyocyte-like cells can be induced in vitro.After the inducement, MSCs have adopted some of the cardiomyocyte's phenotype,with the expression of the cardiac specific proteins,and even beat spontaneously. But there is a short of experiment on human MSCs' inducement research. We are lack of the corresponding proof about the changes of morphology, histology and molecular biology of the cells during the differentiation after the inducement.The stem cells' differentiatin draw assistance from the regulation of stimulus signal coming from outside accompany with intercellular specific transcription course. It has been approved that adult stem cell differentiation into cardiomyocyte-like cells...