The Brain Immune Response-related Nuclei

Neuroimmunomodulation is a new field of neuroscience. A large number of evidence shows that there is bidirectional communication between the nervous system and the immune system.According to previous data, after recognizing the nonself or modified self antigens by the immune system, activated immune cells could send the immune information to the central nervous system. After receiving signals from the immune system, the brain may respond by emitting regulatory signals. But to present, our knowledge about the neurocircuitry within brain related to the peripheral immune response is still fragmentary.The present study consists of the following five parts: 1. Fos expression in CNS during the immune response evoked byantigens: (1) The effect of SRBCs inoculation on Fos expression in the ratbrain - a study with humoral immunoresponse modelFour days after SRBCs inoculation, at the peak of the antibody production, strong Fos expression was observed in many brain areas. In hypothalamus, paraventricular neucleus showed robust Fos expression, and almost 80% Fos positive cells in the antior magnocelullar part and the medial magnocellular part of PVN was oxytocinergic. Fos positive cells in the SON mainly located in the dorsal part. Strong Fos expression was also seen in the SOR,AMPO,AVPO,MnPO, AH, DMH, Arc, SCN and SuM. Moderate Fos expression was observed in the MPO, PH, TC and LH.In forebrain, strong Fos expression was induced in Acb and FStr nearby, LSV, BSTL, BSTV, CeA and BLA. In addition, in the brain area near the lateral ventricle, many small cells were Fos immunoreactive. Strong Fos positive cells located in the cortex. However, only light Fos...