Brain Natriuretic Peptide In The Diagnosis Of Acute Myocardial Infarction In Experimental And Clinical Research

BackgroundAcute myocardial infarction(AMI) is one of the most life threatening diseases in modern life. How to diagnose AMI rapidly and accurately is a very important subject facing all the cardiologist in clinical practice. However,many patients with AMI in the emergency department frequently constitute an analytical dilemma to physicians,particularly when the electrocardiography(ECG) is non-diagnostic or creatine kinase MB (CK-MB) and cardiac troponin I(cTnI ) don't increase significantly during the 0-4-h period after the onset of AMI.Cardiac markers have been used to diagnose AMI widely in clinical practice at present.But these cardiac markers have many limitations in the early diagnosis of AMI,especially during the 0-4-h period after the onset of AMI.Although myoglobin(Mb) increases early in patients with AMI, it exist in blood stream in a brief space of time. cTnI plays an important role for the diagnosis of AMI and its specificity is very high,but it usually doesn't increase enough during the first hours after onset of AMI.So it is urgent to seek a new blood marker for the diagnosis of AMI in early stage,especially during the 0-4-h period after the onset of AMI.Brain natriuretic peptide(BNP) has been found to play a major role in the early diagnosis of congestive heart failure(CHF) and has been reported to be significantly prognostic predictor of CHF and acute coronary syndrome(ACS).