Spleen Dampness Huoxuetongmai Method Treatment Of Chronic Lower Extremity Venous Edema Clinical Studies

The study includes four parts : the first part is modern medical literature reviews , the second part is a TCM literature reviews ,the third part is a summary of Professor Chen Shuchang,s experience and hypothesis about the mechanism and the therapeutic principle of chronic lower limb venous edema (CLLVE for short) and the fourth part is a randomized control clinical trial of 54 cases of CLLVE patients.In the first part,the author reviewed the concept of CLLVE and diagnostic and therapeutic studies of the later 20 years of west medicine on it.In the second part,the author explored the derivation of ancient attitudes towards the mechanism and treatments of CLLVE-like diseases and summed up modern TCM studies of CLLVE on both the mechanism and treatments.In the third part, the author discussed why professor Chen had laid emphasis on the concept of CLLVE.In simple words, she believed that the diseased part of CLLVE is in the blood vessels and the stasis or stagnation of blood circulation is the mechanism. Based on which, Professor Chen emphasized that we should pay more attention to activating blood circulation in addition to strongthening spleen energy and eliminating dampness in treating CLLVE.In the fourth part, To evaluate the efficacy of strengthening spleen energy and activating blood circulation at the same time to eliminating dampness in treating CLLVE,100 diseased limbs were enrolled in the trial, with patients in the treat group (n=53) receiving Qushixiaozhong Capsulae(strengthening spleen energy and activating blood circulation at the same time to eliminate dampness) 6 pills three times a day and that in the control group (n=47) receiving Shenlingbaizhu Pills(only strengthen -ing spleen energy to eliminate dampness) 5g three times a day for 8weeks.At the points of 0 week,2 week,4 week,6 week and 8 week, parameters of 6 symptoms , 6 signs ,perimeter of legs (15 cm above knee),calfs(15cm below knee) and ankles was messured. Changes of RCT, Vmax,thickness of skin and subcutaneous tissue,VRT,MVO and SVC etc.were observed at 0 week,4 week and 8week with methods such as CDFI , PPG and PCR etc.. The outcome showed that the integral of clinical symptoms and signs in both groups improved significantly while total efficacy rate were 87.72% and 60.47% separately,the excellent rate were 68.42% and 34.88% separately, which indicated that treat group were more excellent in treating CLLVE(P < 0.01). CDFI , PPG and PCR showed that reflux continuous time, the maximum velocity of reflux,the mean value of MVO ,the mean value of SVC, thickness of subcutaneous tissue and thickness of skin decreased significantly while mean VRT prolonged in treat group(P < 0.05). The outcome showed out that reflux of venous blood reduced,collateral circulation was formed and stagnation of fluid in subcutaneous tissue and skin decreased at the same time which gave us part reason of excellent efficacy of treat group. According to the study,the author concluded that Qushixiaozhong Capsulae was more excellent than Shenling -baizhu Pills which indicated that activating blood circulation could improve the efficacy on the basis of strengthening spleen energy to eliminate dampness in treating CLLVE.