Study On Lithium Sodium Potassium Niobate Novel Biological Piezoelectric Ceramic

For piezoelectric effect of bone is similar to piezoelectric ceramics in electrical industry.Inorder to develop a novel biological ceramic for imitating piezoelectric effect, component and structure of nature bone, two kinds of biological piezoelectric ceramics were fabricated by lithium sodium potassium niobate (LNK) piezoelectric ceramic mixed respectively with hydroxyapatite (HA) and [3-tricalcium phosphate (TCP) at different ratio. To study the substitute material piezoelectric property that matching bone, the piezoelectric and bioactive of samples were examed.The designe of bioceramic have many advangtage: Firstly, as the main inorganic component of nature bone, HA and TCP have excellent biocompatibility and are widely used in medical treatment as bone repair. Secondly, TCP was already proved that have biodegradation, osteoconductibity and even osteoinductivity. Finally, bioceramic with exellent bioactivity and piezoelectric property may improve the osteoinductivity.The studay is composed of three part experimentation.1 The preparation and electric property of piezoelectric bioceramic.With the conventional industrial methods being explored and optimized, piezoelectric ceramic mixed respectively with hydroxyapatite (HA) andβ-tricalcium phosphate (TCP) at 1/10, 2/8, 3/7,4/6, 5/5, 6/4 and 7/3 ratio. Result suggested that the piezoelectric characteristic increased corresponding-ly with the increase of LNK amount.2 Bone-like apatite inducing activity of the piezoelectric bioceramic.The deposition of bone-like apatite on the samples surface is crucial to the osteoinductivity. In vitro, bone-like apatite inducing activity of samples were examed by simulate body fluid(SBF), results showed that apatite crystal formed mostly on negative charged surface, less in the positive; TCPLNK1/10 negative surface have better inducing activtity than other.3 The effect of piezoelectric bioceramic on the growth of rat periosteum derived osteoblast in vitro.After seeded respectively on the samples, Osteoblast characteristics were evaluated by means of scanning electron microscopy (SEM), MTT assay and alkaline phosphatase (ALP) activity assay was explored. The resulted suggested that the negative surface of samples possesses better osteogenesis potential than the positive; The growth and ALP activity of osteoblast on the TCPLNK1/10 negative surface were significantly higher the others; Based on these findigs, these results may provide a basis for the preparation of novel biological piezoelectric ceramic, and the negative surface with its bone inductivity and bioactivity that may permit the imitation piezoelectric effect of nature bone, for bone regeneration.