Curative Effects Of Zexietang On Metabolic Syndrome Rats And Its Mechanism

Objective To explore the therapeutic effects of Zexie Tang on Metabolic syndrome(MS) rats as well as to make a study on the molecular mechanism. Methods Rats models(males and females) of Metabolic Syndrome were established by high sugar & fat diet, then they were randomly divided into 3 groups, including ZeXieTang decoction(TCM group), sibutramine (western medicine group) and saline group. After 4 weeks of oral administration and high sugar & fat diet, the changes of body weight and associated indicators, the levels of fasting blood-glucose(FBG), lipids, fasting insulin, serum leptin and plasma NPY were examined respectively. Meanwhile, Ghrelin, TNF-α, NPY and Y1 receptor subtype (NPYY1R,Y1R) in hypothalamus, NPY and Y1R in pancreatic islets were tested by immunohistochemistry. The density mean was analyzed by image-pro plus6.0. Results The body weight, levels of FBG, lipids, insulin, leptin and plasma NPY were reduced significantly in TCM group. The density mean of Ghrelin, NPY and Y1R in hypothalamus and of NPY and Y1R in pancreatic islets were significantly lower in TCM group than those in saline group. Conclusion Zexie Tang can inhibit the growth of body weight of MS rats, reduce the level of FBG and regulate lipid metabolism probably by inhibiting the synthesis of NPY and the expression of Y1R in hypothalamus and pancreatic islets, by which restrained the synthesis of Ghrelin in hypothalamus, regulated the excitability of the feeding center, improved the functions of pancreatic islets B cells and reduced the insulin resistance and leptin resistance.