| Professor Zhao Guanying has accumulated rich experience in diagnosis, treatment and prevention of senile diseases.He thinks the pathogenetic characteristics of the aged can be summarized as "deficiency" and "stagnation", and "deficiency" is the basis and leads to "stagnation",including qi-stagnation, phlegm-blockage and blood-stasis.Because of deficient vital-qi and stagnated pathogenic qi,the senile diseases are difficult to be cured,multi-viscera is usually involved,and mutation is prone to happen.Combining traditional chinese medicine with west medicine,syndrome differentiation with disease differentiation,macrocosm with microcosm,professor Zhao raised a mode called the trinity of syndrome differentiation,which emphasizes the combination of disease,stage and syndrome.He emphasizes regulation and harmony in treatment, combines reinforcing deficiency with removing stagnation.Among the five viscera,he especially emphasizes protecting kidney and spleen.He also underlines health preservation and eliminating pathogenic factors physically and mentally in the beginning.Parkinson's disease(PD) is a kind of degenerative disease of the central nervous system in the aged.The professor analyzed the associativity between renal-deficiency blood-stasis and the pathology of PD from such aspects as age of onset,symptoms,location,duration of disease and molecular biologic mechanism, etc.He proposed that in the pathogenesis,deficiency of kidney and debility of marrow is the internal condition,and blood stasis is the necessary factor.Renal deficiency and blood stasis is the fundamental pathogenesis of PD.Strengthening kidney and activating circulation is the therapeutic principle of PD.The clinical research on Bushen Huoxue Yin(BHY) indicated that the PD curative effect in integrated traditional and western medicine group(ITWG) was significantly better than that in single western medicine group(SWG),especially on improving non-motor symptoms,motor fluctuation,such as sleep,mood,physical discomfort, cognition,on-off phenomenon,deterioration at the end of dose,etc.It showed satisfactory synergy and attenuation.It was found that the curative effect of the decoction(BHY) was more permanent and stable.Compared at each time point,the severity was relieved gradually in ITWG,as in SWG it relieved after one-month treatment but rose as time going on,UPDRS score showed an upward trend.For H&Y 2.5～3 stage, the curative effect in ITWG was significantly better than in SWG,which indicated that treatment with combined traditional Chinese medicine and western medicine had important clinical significance for the higher stage of PD.The decoction (BHY) relieved muscle rigidity more effectively than tremor.It could improve hypokinesia and quality of life fundamentally.The study on neurotransmitter suggested that the mechanism of improving affective disorder and cognitive handicap was relevant to elevating 5-HT and NE.It was also indicated that the pathogenic factors of PD was multiple,many symptoms couldn't be relieved effectively only by symptomatic treatment with L-dopa.The whole adjustment of Chinese medicine and the neuroprotective effect of decoction indicated that treatment combined traditional Chinese medicine and western medicine,which could make up for each other,may be the best modality of PD system treatment.
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