Exploring The Scientific Connotation Of "Defensive Qi Rooted In Kidney" Based On The Differentiation Of Hematopoietic Stem Cells Into Immune Cells

Based on related theories and laboratorial researches, the foundational theories of "defensive qi rooted in kidney" and the functions and mechanism of "warm kidney to activate yang" are discussed.In view of the similarity of the function of defense mechanism in modern medicine and "defensive qi" in traditional Chinese medicine, the following theories about "defensive qi rooted in kidney" which are relevant to modern immunologic mechanisms such as "defensive qi", "warm kidney to activate yang", "kidney", and so on are introduced to demonstrate the etiology and pathology of "the lack of defensive qi" and elaborate the essence of "defensive qi rooted in kidney".Besides, by means of discussing syndrome of decoction GUI ZHI(Ramulus cinnamomi)JIA FUZI, combining with Shang Han Lun and comments of previous experts, the notion that hematopoietic stem cells (HSCs)is one of the substantial foundation of "kidney" in the process of "warm kidney to activate yang" is putting forward.On the basis of the theories above and related researches made by other doctors, the idea that warming kidney works by activating HSCs to differentiate into antigen presenting cells (APCs) is proposed. On the overall level, model of immune suppression is used to research and evaluate the function of FUZI. The conclusion is that FUZI may improve the living standards, prolong the lifespan and oppose to Cyclophosphamide.In addition, a further research is made to find out the secret how FUZI works by using HSCs and dendritic cells which have been proved to be the most important APCs. In the process, some modern theories and experimental methods like flow cytometry are used. The results show that the DC Marker and Sca-1 may be effected by FUZI, but no statistical significant between-group differences have been found. To explore the mechanisms in this course of event, some further considerations are necessary. Focus on the differentiation direction of stem cells, the immune function in skin and mucous membranes may be able to help.