Clinical Research Of Clinical Symptom, Objective Sign Of Combined Moxibustion And Zhisanzheng (MAZ) For Treating Post-stroke Depressive Disorder (PSD) Patients

ObjectiveThe research deployed clinical epidemiology,clinical scientific research technology and mathematical statistics analytical method and marched clinical ran-control study, which was observed the influence on clinical symptom, objective sign of combined Moxibustion and Zhisanzheng (MAZ) for treating post-stroke depressive disorder (PSD) patients in order to approach the clinical curative effect and safety.MethodsTo select the 60 cases candidate that treated in the clinic service department of Tainan hospital in Taiwan from Dec.2008 to Dec.2009, which coincidence with the bolting standard of PDS. Divided the candidates at the ratio of 1:1 in treatment group and the control group randomly. Each group was 30cases. The treatment group was treated by combined Moxibustion and Zhisanzheng and the control group was treated by the Zhisanzheng treatment. Alternate day treatment a time,15times as a course of treatment, and observe in a course of treatment. Hamilton's depression scale and self-rating depressive scale (SDS) were used for evaluating before and after treatment. And the safety was detected. Observed the clinical curative effect of patients by the subtract ratio of HAMD total scores which was decreased following the improvement of the disease. More then 75% was clinical control. More then 50% was excellence. More then 25% was improvement. Less then 25% was ineffective. Database was set up with the software of Epi Data3.1. The statistical analysis was used with the software of SPSS15.0. Measurement data was represented by mean±standard deviation (), numeration data was represented by constituent ratio (%). The classification data was observed using 2 Test and the ranked data by Wilcoxon rank-sum Test. Independent T-test or Wilcoxon rank-sum Test was applied for group comparison. Matched t-test or Wilcoxon matched-rank-sum test was applied for self-AP:PA comparison. The software of Graph Pad Prism 4.03 was used for statistical figure.ResultsThe research totally gathered 60 cases of qualified subjects which were medical outpatient. There were 32cases men, and 28 cases were women, the age was 43 to 69years old, the course of disease were from 0.5months to 60 months. There were 30 cases in the experiment group (18cases were men,12cases were women), While there were 30cases in control group (14cases were man,16cases were women). The average age of two group was 65.79 years old and 63.16years old. The average of disease course was from 10.37months to 9.80months. Comparability of baseline characteristics of patients in the two groups of gender, age, disease course, extent of disease, HAMD score, HAMD seven factor score and SDS score, there was no statistical significance analysis which showed that the baseline data between the two groups were comparable. After one-month treatment, there was statistical significance between the experiment group and the control group on HAMD score and SDS score. There was statistical significance of the comparison within-group (P<0.05) Furthermore, the experiment group changed more apparently after treatment than the control group on the HAMD score and SDS score. There was statistical significance between the experiment group and the control group (P<0.05).HAMD evaluation was consisted with seven factor score, including anxious/ somatization,body weight,blockage,cognitive handicap,change from morning to night,sleep disorder and feeling of despair. After one course of disease, the treatment group was better than the control group on improving the seven factor score except body weight (P<0.05). The treatment group was better than the control group on improving the anxious/somatization,cognitive handicap,change from morning to night and feeling of despair (P<0.05).There was not significant difference between two groups in the body weight,blockage,sleep disorder (P>0.05).The experimental group had 30 cases,5 cases were clinically controlled, 16 cases had markedly effective,4 cases had effective curative effect,5 cases had no effective, and the total effective rate is 83.3 percent. The control group had 30 cases,2 cases were clinically controlled,8 cases had excellence curative effect,11 cases had effective curative effect, ineffective was 9 cases; the total effective rate was 70.0 percent. The difference was statistically significant between two groups in the clinical effective (P<0.05), However, there was not significant difference in the total effective rate (P>0.05).There was not statistically significant on blood tes,urine test,stool test,liver and renal function,electrocardiogram after treatment. It was considered that two groups of medicine were safe.ConclusionConcluded the result of the research, the combined Moxibustion and Zhisanzheng treatment group has a potency of curative effect on treating the disease. It can not only effectually decrease the HAMD score and SDS score but also do well in improving depressive disorder symptom. The treatment group was better than the control group on improving the anxious/somatization,cognitive handicap,change from morning to night and feeling of despair. And the clinical cured rate of the treatment group was higher then that of the control group. Further more, it was safe and effective and has the potential of further development used combined Moxibustion and Zhisanzheng for treating PDS.