Basic Research Of The Near-infrared Blood Volume Spectroscopy In Non-invasive Glucose Testing

Diabetes is a common chronic diseases,endanger human health seriously. Currently, conventional testing methods of blood glucose are invasive detection. Thence, frequent blood testing will bring patients unnecessary suffering and economic burden, which makes continuous monitoring unpractical. Near infrared spectroscopy (NIR) glucose detection is an analytical technology with noninvasive, no infection advantages. This technology possesses very important practical significance in alleviating pain of patients and achieving continuous glucose concentration monitoring.This dissertation summarizes the results of previous studies, and generalizes the currently key challenges which NIR noninvasive glucose detection faces:①weak signal;②interference of tissue background;③blood volume changing. NIR subtracted blood volume spectrometry can deduct the tissue background interference in space and time domain, and obtain effective spectrum information of blood.A detection system for near-infrared volume wave is built. Some basic problems involved in NIR subtracted blood volume spectrometry are studied.①Determine the best testing location for subtracted blood volume spectrometry.②Propose the substitute band of combination in NIR spectroscopy noninvasive glucose detection.③Propose the time resolution requirements of NIR spectrometer.④Estimate the repeat signal to noise ratio requirements of NIR spectrometer.⑤Investigate differences of pulse peak to peak value between the patients of different ages and different diseases.⑥Propose the vascular occlusion method, which can increase the volume difference of human body blood, and then lower the requirements of the signal to noise ratio for one order of magnitude.