| Gender differences in cardiovascular disease, and it is found that estrogen has myocardial protective effect, but the exact mechanisms are not fully clarified. However, recent studies suggest that estrogen may modulate various endogenous myocardial protective mechanisms. UCNs-CRHR2 system as an endogenous myocardial protective mechanism has been widespread concerned in recent years. The first part of this study found that estrogen can up-regulate CRHR2 expression in myocardial cells, thus enhancing the protective action of UCN. UCN-induced myocardial protective action has been received extensive attention, but the mechanisms are not well understood. In the second part, we found that UCN up-regulated the expression of SGK which is a myocardial protective related molecule. This suggests that UCN up-regulating SGK level may be an important aspect in its protective action. In the third part we studied estrogen on the SGK expression, and discussed the relationship between estrogen, UCNs-CRHR2 and SGK. We found that estrogen increased SGK expression via UCNs-CRHR2 dependent pathway, which may be an important molecular mechanism of estrogen in enhancing heart resistance to ischemic injury.
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