The Influences On The Neuroendocrine And Behavior In Experimental Depression Rats By Swimming

Through analysis method of some relevant research of the depression and through animal's experiment studying, this paper probes into the function link and mechanism on the exercise of swimming preventing depression. Set about from the position of the brain in the illness and treats of the depression, the research studies the influence of the sports not only to monoaminergic neurotransmitter in the hypothalamus, the hippocampus tissue and the blood plasma, but to the hypothalamus-pituitary-adrenocortical axis function state of the chronic unpredictable mild stress model of depression rats. Thus it offers experiment materials and theoretical foundation that can be consulted for the hypotheses that sports can prevent the depression. At the same time, it also offers physiological, biochemical evident for the theory that sports exercises can promote the psychological health and better the bad emotion.To probe into the swimming' prevention function to the depression and analyses its mechanism, this paper launches research from the aspects of theory and animal's experiment.The animal's experiment study combines the two ways of classical animal depression model preparation: stress and rised separately, copying the chronic unpredictable mild stress model of depression rats. In this experiment, there are 60 SD rats. They are divided into 5 groups at random: control group, exercise group, depression group, exercise + stress group, exercise + stress + exercise group. This experiment lasted 14 weeks. In the top 10 weeks, except the control group and the depression group, the rest three groups all received the swimming exercise. The swimming plan is like this: In the first week, swim 10 minutes everyday in the top 3 days, swim 20 minutes everyday in the later 3 days, swim time increase 10 minutes every 3 days, increase 20 minutes every week, swim for 6 days every week. In the third week, the swimming time has increased to 60 minutes. Keep the swimming time for the following 7 weeks. 10 weeks later, except the control group and the exercise group, the rest three groups received a 28-day-long the chronic unpredictable mild stress under the situation of separately raised. During this period, the exercise group continued the swimming. The control group is normally raised until the end of the experiment; the exercise + stress group stop swimming during the stress period; the exercise + stress + exercise group continued the swimming during the stress period. During the whole course of the experiment, the researcher regularly tested the animals' behavior, diet, 1% of the sugar solution consumption and weight increase. After the experiment, being beheaded kills the animals. The researcher separation, collected samples and examined the amount of the monoaminergic neurotransmitter in the hypothalamus organization, the hippocampus organization and the blood plasma through the method of fluorescence. She also examined the amount of the corticotrophin releasing hormone, adrenocorticotrophichormone and corticosterone in the hypothalamus organization, the pituitary, the hippocampus organization and the blood plasma through the methods of radio immunoassay and fluorescence. At last, the results were compared and analyzed. Through an analysis of experimental result, draw the following conclusion:1 .The influence of the chronic unpredictable mild stress to the body is extensive, which included the behaviouristics changes, the off-balance of the monoaminergic neurotransmitter and the Imbalance of the hypothalamus-pituitary-adrenocortical axis function. And this is the biochemical-physiological foundation that bring out the depression .2.The chronic unpredictable mild stress resulted in the change of a series of behavior indexes of the depression group rats: the slow-down in the weight increase; the decrease of the consumption of food and the 1 % sugar solution; the reduction of the crossing score and the rearing score; the decrease of thymus gland weight; he increase of the adrenal gland weight. All these showed the characteristics of the clinical de...