Modeling Calculation Method And Experiment For Micromixer And Microreactor

Currently, researchers have studied micromixer and microreactor, and some devices, such as separate and merge micromixer, chaotic micromixer, enzyme reaction microreactor and immune reaction microreactor have been provided. These devices have been applied in cell research and drug research, but some computational problems still exist. For the first, calculated amount is large. Micromixer and microreactor usually integrate microchannels and microchambers with micrometer scale and millimeter scale, and sample mix and reaction is complex in microchannels and microchambers. When calculating micromixer and microreactor. a large number of grids for multiscale geometric structure need be divided, and multi-field coupling factors need be considered. So, calculated amount will increase. For the second, calculation is not flexible. A wide variety of structures are contained in micromixer and microreactor. Numerical simulation usually adopt a method to design these structures, rather than in accordance with the characteristics of the various structures, resulting in poor calculation flexibility.Aim at the above mentioned problems, this paper proposes the modeling calculation method for micromixer and microreactor. Micromixer and microreactor usually consist of the simple unit, such as the straight channel and the complex unit, such as the mixed channel. The modeling calculation method effectively uses the structural feature of micromixer and microreactor. Its basic design idea is that different design method is used toward different unit. For the simple unit, macro-model is set up, while for the complex unit, numerical model is built. Some mathsmatics methods like the data fitting and interpolation are used to combine the macro model and the numerical medel, and the calculation model of micromixer and microreactor are abtained.By using the modeling calculation method of micromixer and microreactor, this paper tries to do some research work on two-dimentional passive micromixer, three-dimentional passive micromixer and microreactor. The focus of this paper is as follows:The calculation model of two-dimentional passive micromixer is set up. For the sample in the two-dimensional passive micromixer, the macro model of sample concentration distribution in the straight channel of the micromixer was set up based on the separation of variables. The numerical calculation was used to establish the numerical model of the sample concentration distribution in the mixing unit. The macro and numerical model were bridged using interpolation and data fitting to set up calculation model. A micromixer has been designed and fabricated. The concentration distribution of the sample was solved in with calculation model. A micro-mixing test platform was built, and the calculation model was test and verified by experiments.For the sample in the three-dimensional passive micromixer, the macro model was set up based on the separation of variables. Further, the macro model for the offset and deformation of sample concentration distribution in the straight channel was set up. Numerical Simulation was applied in setting numerical model for the mixing unit. The calculation model containing positive peak macro model and distorted peak macro model was set up with interpolation and data fitting. The rib-type micromixer was been designed and fabricated. The concentration distribution of the sample in the rib-type micromixer was solved with established calculation model. The positive peak macro model, the offset and deformation macro model and the calculation model were test and verified on micro-mixing test platform.For the microreactor, the macro model for the change of reactants concentration with the reaction rate constant, and the macro model for the change of reactants concentration over time in the constant channel for the first-oeder reaction were set up. The macro models in the case of the linear and non-linear distribution input of the reactant concentration for the second-order reaction were set up. The global parameters were obtained with macro model, and then as boundary conditions plugged into numerical model. The local parameters were obtained with numerical model. At last, the calculation model for microreactor was set up. A micro-mobility platform was designed and fabricated, and a chemiluminescence detection system was built. The chemiluminescence system of the luminal-hydrogen peroxide-cobalt ion was researched. The relationships between luminol concentration, hydrogen peroxide concentration, cobalt ions concentration, sodium hydroxide concentration and luminous intensity were studied, and the model was validated.