Carbon Nanotube Quito, Function And Performance Study Of Preparation Of Drug Carrier

Nanomaterial-based drug carriers have become a hot spot of research at the field of biomedicine because they allow efficient loading, targeted delivery and controlled release of drugs; therefore, they are promising for biomedical applications. In this paper, we focus on the research of preparation and characterization of multi-functional drug carriers, and the property were also investigated.The main works are summarized as follows:(1) A bifunctional cancer drug targeting carrier (CdSe@Fe3O4/CNTs) was prepared by using chitosan as a bridge to link CdSe and magnetic CNTs, which improved the stability of the entirety; CdSe was linked up with chitosan using covalent bond steadily and kept a good fluorescence. A mechanism scheme was proposed to illustrate the formation process of the nanocomposites. Results showed that the novel carrier has the potential to meet the specific needs in cancer in vivo imaging and targeted cancer therapy.(2) A simple yet novel process was developed where magnetic graphene-CdS (Fe3O4-CdS/G) nanocomposites were prepared by a one-pot solvothermal route in which the reduction of graphite oxide (GO) into graphene was accompanied by the generation of CdS and Fe3O4nanoparticles. The results of vibration sample magnetometry, fluorescence spectra and loading of doxorubicin (DOX) reveal that this new nanocomposite possesses good superparamagnet (44.85emu/g), good fluorescent properties and a high loading efficiency (0.98mg/mg). The efficient, stable, and water soluble nanocomposites are confirmed to be suitable for biomedical applications.(3) A novel triple functionalized drug delivery system has been synthesized by encapsulation of superparamagnetic graphene oxide (GO) and doxorubicin (DOX) with folic acid (FA) conjugated chitosan (CHI). The carrier possesses a high loading efficiency (0.98mg/mg) and a prolonged release property for the effect of CHI. Also the mechanisms of the release of DOX at different pH have been investigated, by monitoring the time dependency of the accumulative drug release. Results show that lower pH values lead to weaker hydrogen bonds and degradation of CHI, which result in a higher release rate. Especially, this system could be applied as a dual-targeted drug nanocarrier by combined biologically (active) and magnetically (passive) targeting capabilities, which could realize the efficient drugs location and recognition.(4) A novel approach for preparing strongly green-photoluminescent graphene quantum dots surface-passivated by polyethylene glycol (GQDs-PEG) has been developed. The photoluminescence (PL) quantum yield of the GQDs-PEG with360nm emission was about18.8%, which was higher than the pure GQDs. Moreover, the high specific surface area and photoluminescence of GQDs-PEG endowed its high loading capability (2.5mg/mg) to load drugs and can be observed without further modifying, successfully demonstrating the GQDs-PEG suited for cell imaging and drug carrier.