Preparation And Application Of Novel Functional Materials As Drug Delivery Systems

In recent years, functional materials have obtained compelling achievements which are underpinned by the latest advancement of physical, chemical, biomedical and engineering sciences through the multidisciplinary teams’efforts. Functional materials play a very important role in the field of biomedical application. Drug delivery systems is one of the most effective treatments of illness, and the design and preparation of novel drug delivery systems meeting the human body microenviroment is crucial. To achieve this goal, researchers bring functional materials into the field of drug delivery systems, and further greatly promote the development of drug delivery systems. In this thesis, in order to improve the treatment efficiency of drug, we design and prepare several new functional drug delivery systems, the more detailed novelty of those research can be categorized as following:1. An amphiphilic bifunctional mesoporous SB A-15material (AMPBIF-SB A-15) was prepared by post-synthesis method as a drug carrier. The materials were further characterized by Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen adsorption-desorption measurements and elemental analysis. Ribavirin was selected as the model drug and whose release from both unmodified and functionalized SBA-15were evaluated. The release process indicated that AMPBIF-SBA-15was a pH-sensitive drug carrier, which showed a phased low-release effect to ribavirin in PBS (pH7.4) solution. This study provided a novel drug carrier for ribavirin to improve curative effect of ribavirin.2. A novel Fe3O4@SiO2@poly-L-alanine peptide brush-magnetic microsphere (PBMMs) was synthesized from amine-functionalized Fe3O4through the surface-initiated polymerization of N-carboxyanhydrides. These materials were characterized by FT-IR, TEM, XRD, vibrating sample magnetometer and elemental analysis. Furthermore, the loading and release behavior of ibuprofen and the enrichment of bovine serum albumin on the two materials were investigated. These materials are promising candidates for targeted drug delivery and protein enrichment.3. We described a new glycopolypeptides nanoparticles (GPNPs) composes of a Mn-doped ZnS quantum dots as core and a glycopolypeptides of dextran-conjugated poly(1-alanine) as shell. The loading and release behavior of a model anti-inflammatory drug ibuprofen on GPNPs were investigated and it was shown that the GPNPs have not only a high uptake amount of ibuprofen, but also possess a pH-triggered releasing behavior in the shell of GPNPs. The cytotoxicity studies showed that GPNPs was a low cytotoxic material.4. A class multifunctional carrier of nanocrystalline silicon (ncSi) as core and a water soluble polymer as shell based on poly(methacrylic acid) inner shell and polyethylene glycol outer shell (ncSi-MPM) was synthesized for anticancer drug delivery. The morphology, composition, and properties of the resulting ncSi-MPM have also been characterized and determined by a comprehensive multi-analytical characterization including1H NMR, FT-IR, XPS, TEM, DLS and fluorescence spectroscopy analyses. The size range of resulting ncSi-MPM was from40to110nm under a simulating physiological environment. Doxorubicin (DOX) was selected as a model drug, the loading efficiency of DOX were approximately6.1-7.4wt%for ncSi-MPM. The drug release rate of DOX-loaded ncSi-MPM was pH dependent and increased with the increasing pH. The cytotoxicity studies showed that the DOX-loaded ncSi-MPM provided high anticancer activity against Hela cells. The hemolysis percentages (<2%) of ncSi-MPM were within the scope of safe value. The fluorescent images studies showed that the nanocarriers could track at the cellular level for advance therapy.5. We prepared a class of biologically sensitive functional polymer materials by reversible addition-fragmentation chain transfer polymerization (RAFT) and used as a drug carrier. The functional polymer has a hydrophilic segment of polyethylene glycol (MPEG), and a hydrophobic segment of anticancer drug camptothecin (CPT). Furthermore, the functional polymer can be forming microspheres by self-assembled, and another hydrophobic anticancer drug DOX was also assembled into the above microspheres. The functional polymer was characterized by1H NMR, GPC, DLS, TEM and UV-visible spectroscopy. In addition, in vitro release, toxicity assessment and cellular imaging of the functional polymer were also evaluated. The results show that the functional polymer is not only has a high drug loading capacity, but also can combine with the anti-cancer treatment of DOX. Furthermore, the cumulative release was related to the concentration of glutathiose (GSH). Due to the fluorescence properties of the drug itself, the functional polymer can be achieved in the distribution of the drug on the cell level track...