Design, Fabiracation And Applications Of Novel Intelligent Drug Delivery Systems Based On Supramolecular Interactions

Intelligent drug delivery systems (DDSs) which are driven by supramolecular interactions have attracted increasing attentions in biomedical application in recent years. Since these DDSs exhibit both highly specific and stimulus-response performances. Here we designed and synthsised a series of novel intelligent drug delivery systems based on supramolecular interactions, and were investigated their stimulus-response properties and controlled release behaviors.Chapter1presents a detailed review about recent progress of intelligent polymeric drug delivery systems and applications of cyclodextrin in supramolecular chemistry and biomedical areas.In Chapter2, a new "Plug and Play" polymeric template with the driving force of host-guest interaction between β-CD and naphthalene-modified functional groups was designed and studied. Multiple functional groups can be loaded into the template directly and conveniently. Importantly, the "Plug and Play" effect of the polymeric template is reversible and the functional groups could be removed from the polymeric template conveniently by adding AD-HC1. The studies on the cell viability and phagocytosis proved that the loading and unloading process of this template could be realized in vitro.In Chapter3, a novel template was further designed for photo controllable drug release. Multiple functional groups can be loaded and unloaded onto the template via UV irradiation. Importantly, the template can inhibit loaded drug being up-taken by normal cells. However, upon the irradiation of UV light to the target site, such as tumor tissues, the loaded drug can be released from the template quickly and thereafter endocytosed by target cells to achieve the desirable cure effect.In Chapter4, photo-switchable microcapsules were fabricated based on Layer- by-Layer (LbL) method. The LbL assembly and durg-loading dirving force of these microcapsules were host-guest interactions between α-CD and Azo. Since the interactions between α-CD and Azo were photo-sensitive, the capsules could be dissociated with the irradiation of UV light, followed by the release of the model drug, α-CD-RhB. Compared with traditional drug-loading approaches such as chemical bonding and physical absorbing, our supramolecular drug-loading system has a facile loading process, ideal bonding strength and photo-switchable behavior. These photo-sensitive microcapsules exhibit great potential in biomedical applications.