Application Of Electrochemistry In Medicine Syntheses

PART 1A major portion of the world population is dependent on plant kingdom for the treatment of various ailments. Therefore, the present work was aimed to isolate several active constituents from medicinal plants, Cirsium arvence (C.arvense). Several biologically active constituents (polyphenolics) were isolated from ethyl acetate and n-butanol soluble fractions. The constituents were isolated and purified by Column Chromatography (CC). The purified compounds were characterized by IR, HNMR and 13CNMR and Mass spectrometry. Theses constituents were screened for their biological activities which showed significant activity.PART 2Pyrimidines are an important group of heterocyclic compounds and play a vital role in the field of medicine and pharmaceutical industry. Keeping in view the diverse role of pyrimidine based compounds, we aimed to synthesize some new Pyrimidine derivatives, namely, (2,6-Bis-(4,6-dimethyl-pyrimidin-2-ylsulfanyl)-benzene-1,4-diol),(3,5-Bis-(4,6-dimethyl pyrimidin-2-ylsulfanyl)-2-methyl-benzene-1,4-diol),(3,5-Bis-(4,6-Dimethylpyrimidin-2-ylsulfanyl)-2-methoxy-benzene-1,4-diol) by electrochemical method, treating hydroquinone with 4-6-dimethylpyrimidine-2-thiol. The synthesized compounds exhibited significant antibacterial and antifungal activities.Sulfanyl compounds are known to have anti-cancer, anti-viral and anti-tumor. Therefore, we proceed to synthesized new sulfanyl derivatives by electrochemical method. Catechols were oxidized electrochemically in the presence of marcapto-benzoic acid to syntheses sulfanyl compounds. Furthermore, we studied the effect of pH on catechol both in the presence and absence of marcapto anion and found that basic media is most suitable to synthesize these compounds. Preliminary antibacterial activities indicated that these compounds could be potential source of antimicrobial agents.PART 3Organic compounds containing fluorine have broad spectrum biological activities, and therefore, a need exists to synthesize these compounds by a more effective method. Electrochemical method is commonly used for syntheses of fluorinated organic compounds under different experimental conditions. Previous findings reveal that a number of ILs, like Et3N.3HF, Et4N.4HF, Et3N.5HF, py-HF etc has been used as fluorinating agents with no satisfactory results. In order to get maximum product synthesis, we attempt to synthesize fluorinated compounds in the presence of ionic liquid (Et3N.3HF) which could behave as a source of fluorine and also act as a solvent. Good results were obtained with respect to product yield and purity and therefore, our findings may be of significant importance in the synthesis of fluorinated compounds.