Dynamic Impact Of The Specific Acupoints Of The Shaoyang Meridian On Brain Function Of Migraineurs:a FMRI Study

Objective:To observe the clinical effects of punching the specific acupoints of the Shaoyang meridian on migraine without aura, and the dynamic impact on the subjects related brain regions and functional connectivity of brain networks, which can provide new evidence for the central mechanism of the specific acupoints treating migraine according to the meridian.Methods:32migraineurs who matched the inclusion criteria were randomly divided into2groups:the specific acupoints according to meridian group (SAG)and non-acupoints group (NAG). Each subject received acupuncture once per day and totally for20times in4weeks. Clinical evaluation and resting-state fMRl scans were Performed on each group before, during and after treatment. The characteristic of brain resions and functional connectivity in eaeh group during and after treatment were investigated.Results:1. the clinical effects of two groups(1) The Pain Visual Analogue Scale (VAS) score descended remarkable in two groups after treatment(p<0.05); furthermore the alter of the SAG is better than the NAG (p<0.05); the alter of VAS score of the SAG at both secondary week and fourth week are better than the NAG (p<0.05).(2) the Migraine-specific Questionnaire score in three field significantly improved in two groups after treatment(p<0.05); the alter of the SAG is better than theNAG(p<0.05).(3) The subject compliance of two groups is98%and90%, the subject compliance of SAG is better than the NAG(p<0.05); the subject satisfaction of two groups is80%and20, the subject satisfaction of SAG is better than the NAG(p<0.05). 2. Results of the image data of resting-state fMRI(1) Dynamic regulation of two method on the brain regions of subjectsThe Reho of the related brain resions of subject in SAG showed dynamic descend or rise at secondary week and fourth week, especially at cingulate gyrus, Amygdala, prefrontal cortex et al; and compared to the secondary week, the number of brain reason having Reho significantly rised at fourth week; The Reho of the related brain resions of subjects in NAG showed dynamic descend at secondary week and fourth week, and compared to the secondaryary week, the number of brain reason having Reho significantly decended at fourth week.(2) Dynamic regulation of two method on functional connectivity of the brain network of subjectsPunching the specific acupoins according to the meridian can dynamic regulate the brain network of the subjects, showing dynamic intensity rise or descend of functional connectivity, and dynamic number rise or descend of related brain resions, especially at cingulate gyrus, prefrontal cortex et al; Punching the non-acupoins can not dynamic regulate the brain network of the subjects, showing dynamic intensity escend of functional connectivity, and dynamic number descend of related brain resions.Conclusions:1. Compared to non-acupoints, punching the specific acupoints according to the meridian can significantly, continuously, bidirectionally, bilaterally, and dynamicly regulate the related brain resions of subjects.2. Compared to non-acupoints, punching the specific acupoints according to the meridian can dynamicly regulate and modify the resting state network of migraineurs.3. The dynamic regulation of punching the specific acupoints according to the meridian on the related brain regions, including cingulate gyrus, amygdala, prefrontal cortex may be one of the central mechanisms of acupuncture for migraine.4. The dynamic regulation and modifying of punching the specific acupoints according to the meridian on amygdale and the resting state network may be the mechanism of the summative and subsequent effects of acupuncture for migraine.