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Based On Clinical Epidemiological Investigation On The Pathogeny Of Cardio-cerebral Combined Disease And Syndrome Of Tcm Research

Posted on:2013-08-15Degree:DoctorType:Dissertation
Country:ChinaCandidate:Y DuFull Text:PDF
GTID:1224330395479218Subject:Traditional Chinese Medicine
Abstract/Summary:PDF Full Text Request
Purpose:Discusses the cause of disease and heart, syndrome distributioncharacteristics and syndrome elements,Every syndrome elements to each other andclip, transformation and evolution of the objective law,To make the heart diseasediagnosis of traditional Chinese medicine and provide quantitative basis andthe reference standard.Material and method:Based on the core periodical literature, TCM internalmedicine book literature study, standard, the reference authority expertsformulated separately repeated proof of coronary heart disease, angina,atherosclerosis sex thrombosis cerebral infarction, coronary heart disease,angina with atherosclerosis sex thrombosis cerebral infarction epidemiologicalsurvey, cross-sectional survey, in11hospitals altogether collected2947casesof, including heart disease and group982examples, trial group1002examples,encephalopathy group963examples.One-time acquisition meet criteria for thefuture cases of general data, history, TCM symptoms and signs information,, andset up a corresponding database.Coronary heart disease, angina merger withatherosclerosis sex thrombosis for cerebral infarction group, are used tocoronary heart disease, angina, pure atherosclerosis sex thrombosis cerebralinfarction as control group, through the application of medical statisticscombining medical evaluation of data for the method of comprehensive analysisof three groups of people material contrast and statistics to analyze,verification and the rationality of the theory of mental illness, mental illnessand understanding of the risk factors.Through the application of medicalstatistics combining medical evaluation of data analysis and application ofclustering respectively with logistic regression analysis and structuralequation analysis in mental and disease of traditional Chinese medical syndrome. Results:1. cerebrovascular disease group in982with total cases, men in525cases,accounting for53.46%, women in457cases, accounting for46.54%; In963casesof encephalopathy, men in612cases, accounting for63.55%, women in351cases,accounting for36.45%, both groups male> women; M in1002cases of men in446cases, accounting for44.51%, women in556cases, accounting for55.49%, thefemale> men. Three groups of gender distribution using R*C table methodstatistical results show that P=0.000<0.001, there is a statisticallysignificant difference.2. cerebrovascular disease group with84-year-old age biggest, minimum36years,mean age65.75+/-10.504years; Maximum84-year-old age group trial, the minimum36years, mean age64.23+/-10.955years;84-year-old age group biggestencephalopathy, minimum37years, mean age67.92+/-9.855years.3. three groups of incidence of a disease are beginning to rise up from45,50years old began to rise sharply, after the age of55in the rush hour, and theincidence of mental illness from65years old already was significantly higherthan the heart and the incidence of brain disease,70~80years old betweenthe highest incidence, anxiety and encephalopathy groups of patients55to75years old in almost two decades.4. heart disease, and patients with heart and brain six exogenous pathogenicto wind, cold, ShiXie give priority to, including heart disease and close tothe wind of encephalopathy group and the highest, followed by cold evil, ShiXie,three were compared between the two groups in there were no significantdifferences (P quartile0.05); Trial for cold evil pathogenic highest group,followed by the wind, and ShiXie, and cerebrovascular disease group comparedwith two two both statistical differences; Anxiety and compared with the evilencephalopathy cold evil pathogenic statistically significant, ShiXiepathogenic rate was not statistically different.5.heart disease, heart and brain with the patients with anger, seven emotions pathogenic worry, thought is given priority to, the highest rate in the wrathof the pathogenic, cerebrovascular disease and brain with group compared P=0.439>0.05is no statistical difference, cerebrovascular disease and heartand anxiety and group compared with encephalopathy are very significantstatistical differences; Sorrow pathogenic in time, three groups there were nosignificant differences between; A thought pathogenic is ranked third in theworld, two comparison between two groups and cardio-cerebral diseases and trialof group was not statistically different.6. Heart disease, and patients with heart and brain disease eating habits onthe main partial fatness, partial salty. Partial fat diet resigned first, mostencephalopathy group. cerebrovascular disease group with more than trial group,two comparison between two groups was statistically difference; Cerebrovasculardisease and group of patients with partial salty food more than trial group,a great statistically significant differences, but group compared withencephalopathy not statistically significant, encephalopathy group more thantrial group statistically significant.7. heart disease, and patients with heart and brain disease risk factors ofhypertension diabetes>smoking drinking> dyslipidemia> obesity; High bloodpressure as the major risk factors, followed by smoking. Statistical analysisshowed that the high blood pressure, smoking and drinking group is extremelybetween statistically significant differences; Diabetes in three groups isstatistically significant differences between; Dyslipidemia, obesity in threegroups there were no significant differences between.Three groups of two twocomparison results for: high blood pressure in trial group compared withencephalopathy mergers similar, cerebrovascular disease combination withrespectively and significantly higher than anxiety and encephalopathy group;Cerebrovascular disease groups of patients with smoking rates higher than thetrial group but less than encephalopathy group, the group was higher thanpatients with brain smoking stain group; Three groups of patients has a drinking habit of most encephalopathy, cerebrovascular disease and is the second smallest,and anxiety at least, cerebrovascular disease and trial group and group and thetrial group compared with encephalopathy are statistically significant; In heartdisease and diabetes and heart and anxiety and brain disease were no groupcompared statistical differences, cerebrovascular disease combination and rateand significantly higher than encephalopathy group.8. depending on the results2will close cerebrovascular disease, heart and braindisease patients age of onset divided into three age groups, in this sectionof the foundation, on the risk factors such as high blood pressure by a chi-squaretest,the selection of significant risk factors are binary classificationLogistic regression analysis. Age1center of disease and anxiety compared withbrain, obesity, high blood pressure and heart disease was positively associatedwith disease; Cerebrovascular disease, compared with encephalopathy, obesity,high blood pressure and heart disease was positively associated with disease.Age2center of disease and anxiety compared with brain, high blood pressure,heart disease and drinking and a positive correlation between disease;Cerebrovascular disease and compared with encephalopathy, diabetes, high bloodpressure and heart disease and with a positive correlation between disease.Results patients with stage three age with risk factors by two groups of twoconditions were no more significant differences.9. for the four diagnostic information analysis merger, the inspection frequency>10%of the information center and brain disease group31, a group of18m,encephalopathy group25studies; Listening and smelling frequency>10%of theinformation center brain disease group and eight, trial group four, fiveencephalopathy group; The frequency of information>10%of interrogation andcardio-cerebral diseases group of43, a cupboard group34,36of encephalopathygroup; Cerebrovascular disease and pulse frequency>10%of information of8items, trial group nine, encephalopathy group six; Cerebrovascular disease groupof tongue diagnosis and the frequency of information>10%of23, trial group of20,21of encephalopathy group. More than10%of the information in frequency,pulse and the divisor tongue is lubricious weak white outside, cerebrovasculardisease and contains the heart and brain disease of all other groups fourdiagnostic information symptoms.10. the four diagnostic information to heart disease and group as the researchobject of logistic regression showed that: inspection center and disease andbrain cupboard group spirit of comparison shows such five signs andcerebrovascular disease and positively related, lip purple was negativelycorrelated; Cerebrovascular disease and brain with group compared晄whitecomplexion six signs and cerebrovascular disease and positively related, themouth eyes tongue skewed was negatively correlated; Listening and smellingcenter of disease and brain and stain musical group compared three signs suchas heavy polluted with heart disease and positively related, less gas, DuanQisymptoms was negatively correlated; Cerebrovascular disease and brain withmusical group compared low and signs and cerebrovascular disease and positivelyrelated; Interrogation center brain disease and anxiety and group comparisonshows dizziness six symptoms of the disease and information and cardio-cerebralwas positively related, fever, limb hair is cool, chest pain, approach thediscomfort, dream was negatively correlated;Cerebrovascular disease and braingroup compared with chest pain and symptoms and cerebrovascular disease waspositively associated with, not approach the four symptoms was negativelycorrelated; Pulse examination center and disease and brain stain sank groupcompared pulse and signs and cerebrovascular disease and positively related,short pulse, astringent pulse was negatively correlated; Cerebrovasculardisease and brain group compared with heavy veins, slow veins, fine veins, weakpulse and cerebrovascular disease and positively related, short pulse,astringent pulse was negatively correlated; Tongue diagnosis of disease andbrain center with anxiety group comparison shows tongue state, including fourtough with cerebrovascular disease signs with a positive correlation between, slippery moss, thin coating on the negative correlation; Cerebrovascular diseaseand brain group compared with tongue color purple8signs and cerebrovasculardisease was positively associated with the diagnosis, color coating on the yellow,slippery moss was negatively correlated.11. With the screening of the four diagnostic methods based information index,the K class centers cluster method for four categories of the sample together,on the classification, and on the basis of logistic regression analysis of theclassification, the first kind of logistic regression analysis resultsconsidering such patients represent the debility blood stasis for syndrome; Thesecond category of logistic regression analysis results considering suchpatients representatives to qi and Yin and holding and blood stasis syndrome;The third type of logistic regression analysis results considering such patientsrepresent is phlegmy turbidity syndrome; The fourth class logistic regressionanalysis results considering such patients to represent the qi stagnant bloodstasis syndrome.12.cerebrovascular disease and structural equation in the latent variablesextracted index reflects some clinical corresponding syndrome factor of content;The latent variables the causal relationships between and mutual relationshipreveals the mental illness and the syndrome factor and each other between noise,transformation and evolution of law; Points latent variables should be card havetwo empty combination Yin, points latent variables and the latent variablescausal relationship between the card combination should be extracted have phlegmturbidity and blood stasis, blood stasis, Yin deficiency blood stasis, Yindeficiency of both qi and blood stasis.Conclusions:1. cerebrovascular disease and rates in men than women; Incidence is increasingwith age,55to79years for disease almost two decades; The six exogenouspathogenic to wind, cold, ShiXie give priority to, lots of emotions in anger,cause sorrow, think Lord; Diet or a partial in the fatness, salty; Hypertension, smoking, diabetes, drinking alcohol, dyslipidemia, obesity are cerebrovasculardisease and the risk factors, high blood pressure for the most important riskfactors, followed by smoking.2. in the frequency of the four diagnostic information>10%in addition to thetwo outside, cerebrovascular disease includes anxiety and with the other andall information encephalopathy; About58%of the four diagnostic methods in threegroups of patients with information related degree similar.3.Anxiety and pathological changes of encephalopathy although different, butthe age of six, seven emotions with her, and, food and drink, and partialeosinophilic, risk factors of the same mergers, clinical the four diagnosticinformation most is same, have different disease manage factors, can mergeresearch.4.cerebrovascular disease and atherosclerosis sex thrombosis brain2~8weeksmain blood stasis syndrome, a deficiency of Yin deficiency of both qi and bloodstasis syndrome, qi stagnant qi stagnant blood and blood stasis syndrome, fourcard type certificate, clustering and logistic regression analysis of the methodof combining, we can explore syndromes classification and quantitative diagnosislaws that have a certain feasibility.5.Cerebrovascular disease of disease and syndrome factor, qi qi stagnant, Yindeficiency and blood stasis exists between the causality, application structureequation model analysis method and cerebrovascular disease syndrome elementsand should be card combination with certain feasibility study.
Keywords/Search Tags:ebrovascular disease close, The four diagnostic information, Clustering analysis, Logistic regression analysis, Structure equation, TCMsymptoms
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