Nonalcoholic Fatty Liver Disease Syndromes To Study The Distribution Of The Elements And Lipid Particles Unclogged Arteries Experimental Research For The Treatment Of Nash

Through literature research, clinical research and animal experiment to investigate the knowledge of Chinese medicine in non-alcoholic fatty liver disease(NAFLD).First part, the literature research of TCM syndrome elements distribution about NAFLDObjective:summarize TCM syndrome elements distribution of NAFLD in literature, a nd sort out the common symptoms of the disease, to provide four diagnostic informat ion for making clinical cases observed table. Methods:through retrospective study, ret rieval Beijing University of Chinese Medicine CNKI database, Select all literature whi ch meet the requirements of NAFLD from1989to2011.according to the classificatio n method which was proposed by academician WangYongyan. In the end, summarize the syndrome and syndrome elements distribution of NAFLD in the literature. Results and Conclusions:the TCM syndrome of NAFLD are8types:phlegm and dampness, liver qi stagnation, dampness and heat, liver stagnation and spleen deficiency, phlegm and blood,liver and kidney yin deficiency, qi stagnation and blood stasis, and blood st asis. syndrome elements of disease locations are liver, kidney, spleen, syndrome eleme nts of disease nature are dampness, phlegm, qi stagnation, blood stasis,heat, qi deficie ncy.Second part, the clinical research of TCM syndrome elements distribution about NAFLD.Objective:explore the distribution of NAFLD TCM syndrome elements. Methods:make clinical cases observed table based on literature.collect cases through epidemiological investigation, then use Factor Analysis to analyse and get the TCM syndrome factors distribution of NAFLD. Results:NAFLD TCM syndrome are:liver stagnation and of the fire, liver stagnation and spleen deficiency, spleen deficiency, phlegm and dampness resistance,dampness and heat,blood stasis.syndrome elements of disease locations are liver, spleen, syndrome elements of disease nature are qi stagnation, qi deficiency, heat, dampness, phlegm,blood stasis.Third part, animal experiment of tiaozhitongmai granule to treat NASH.Objective:explore if tiaozhitongmai granule have the effect of lowing blood lipids,in the same time,it will not injury liver. Methods:High-fat diet make rat NASH model, then use tiaozhitongmai granule to treat by gavage. The control group treat with Yiganling tablet, after four weeks, detect liver histopathology and the level of TG、TC、HDL、LDL、ALT、AST and soon. Results:tiaozhitongmai granule can reduce the level of TG、TC、LDL、ALT、AST、 MDA、 Ins.elevate the level of GSH-PX, have little effect on HDL、SOD. Conclusions: tiaozhitongmai granule can low blood lipids of NASH rats. It can reduce transaminase levels and improve liver function., the mechanism may play a role in improving lipid metabolism and insulin status,inhibition of lipid peroxidation.