| Objection:To summarize Professor Chen Jifan’s academic ideas and clinical experience on rheumatism treatment, as well as his incisive opinion of diagnosis and treatment over the systemic lupus erythematous (SLE). Professor Chen Jifan realizes by combining the ancient doctors’knowledge about the pathogenesis of the sickness and the medicine of the treatment over SLE. This has formed the traditional Chinese treatment ideas of SLE based on constitutional research. By researching the constitution of the SLE patients, probing into the physical characteristics, factors and the cause of the disease of the SLE patients. Then apply the Revised Xiaochaihu decoction treatment onto the patients according to their different constitution. Purposeis to explore the pathogenesis of SLE, and observe the clinical efficacy of Revised Xiaochaihu decoction treatment of SLE, to achieve the use of Revised Xiaochaihu decoction to aftercare constitution.METHORD:Follow the outline that has been laid out within the traditional Chinese constitutional theory. The research for120SLE patients who had the medical treatment in the outpatient department and inpatient department of the1st affiliated TCM hospital of Guangzhou TCM University from2010to2011. This investigation with the questionnaire survey based off gender, age, constitution aspects and so on. Then do the statistical analysis to the result; all the patients are randomly divided into three groups:The first group use Prednisone acetate15mg per day. The second group would use Prednisone acetate15mg and Revised Xiaochaihu decoction (Xiaochaihu decoction group is basically with Xiaochaihu decoction, including bupleurumlOg, lanceolata15g, prepared pinellia tuber10g, scutellaria lOg, jujube10g, ginger5g, glycyrrhiza5g. This will mix together with some of the medicine according to different constitutions. Gentleness type constitution just follow the original soup; Qi-deficiency constitution will need to be mixedwith Astragalus30g. Yang-deficiency constitution will need to mix with prepared aconite root lOg (boil first) and then the Yin-deficiency constitution will need to mix with ligustrum lucidum15g、eclipta prostrata15g.After that the phlegm and dampness constitution will need to mix with tuckahoe15g、almond15g; and dampness-heat constitution will need to mix with cortex phellodendri15g、finally the chinese atractylodes10g; combined with the Blood stasis constitution will need to mix with pseudo-ginseng lOg and special diathesis type constitution will need to mix with black cohosh10g、divaricate saposhnikovia root10g. All of this medicine soup should be boiled in the medicine boiled room of the1st affiliated TCM hospital of Guangzhou TCM University. After that place500ml water into each prescription and boil it for45minutes. Please make sure the fire is set at a low setting and only leave150ml of water and take one prescription each day. If it needs to be mixed with prepared aconite root, then you should place750ml of water into each prescription. Then boil the prepared aconite root for20minutes after that mix the other medicine with it and boil it for45minutes with a low fire setting and only leave150ml water.The third group will use MPH group with Prednisone15mg and Hydroxychlorquine400mg per day, and MTX10mg per week. The record of the SLEDAI score should be taken, and the figure of ANA、 ds-DNA、CRP、 ESR、C3、C4and so on. The changes in clinical symptoms and the variety of adverse reactions should be noted after taking the medicine from the three different groups. This should be noted before the treatment and six months after the treatment, so that we can evaluate the efficacy and safety to the three treatment options.RESULT:1. Professor Chen Jifan has been engaged in clinical medicine, teaching, resear-ch and management for nearly50years. Professor Jifan is a very knowledgeable person when it comes to the field of traditional medicine and alternative treat-ments. A person who prides himself with bringing honestly as well as hard work to the workplace. Professor Jifan has a strong background in the field of rheum-atism traditional Chinese medicine prevention and treatment. Using the "Synopsis of Golden Chamber","Inner Canon of Huangdi" and "Treatise on Cold Pathogenic Diseases"and otherclassics’methods and prescriptions to diagnosis and treatment. He advocates pay close attention to the entirety diagnose also stresses highly that treatment should be fundamental and reconciles the Yin and Yang reinforcing and reducing. Professor Chen thinks that Deficiency is a fundamental internal cause of rheumatismand the characteristics of its pathogenesis are various sicknesses mixed together. Thus the best method of a rheumatism treatment is to reconcile the Yin and Yang, combine diseases and symptoms. The treatment is different from person to person, including toxic-purgitive methods, cold-warm drugs and dry-moist drugs etc. Prescription drugs are highly suggested selecting the medicine base on the cause and the current status of the disease, cautiously revise, use parallel medications, worms and vines. Then focus on functional training and psychological counseling. For SLE, Professor Chen would like to give the SLE patients treatment according to their own constitution. Therefore, it enhanced the patients’ability of disease resistance and body reparation. This also improves the clinical effect and reduces mortality as well as prolongs the stabilization and remission of the disease. Professor Chen is good at using the Revised Xiaochaihu decoction for SLE treatment. The prescription was considered as the Chinese classic prescription, its cold-warm methods, toxic-purgative methods, up-descending regulations, comprising Shao-yang, smoothing San-jiao, regulating Qi. Revised Xiaochaihu decoction is a very refined as well as efficient and compatible with the human body. Toxic-purgative methods are used alternatively. He Considers both the exterior and interior of the body, reconciles theYin and Yang. Professor Chen thinks that theRevised Xiaochaihu decoction is the appropriate prescription for the SLE treatment. Apply itaccording to different patients’constitutions, it works every time.2. Constitutional investigation:the SLE has extremely significant differences on gender women’s incidence of disease is higher than men (P<0.01), there is a significant difference of incidence in the21-40year-old age group(P<0.05). In a survey done on patients with SLE, their constitutional types commonly found Qi-deficiency constitution Yang-deficiency constitution Yin-deficiency constitution and Impressed constitution. That age has a significant influence on patients of Yang-deficiency constitution and Wet-heat constitution. The duration of disease have a significant effect on patients of Yang-deficiency constitution.3. Three kinds of treatment options:Three kinds of treatment options are effective in clinicalefficacy. Among three of them, the effectiveness of the first group is the lowest while the third group is the highest. In terms of clinical safety, the second group is significantlyhigher than the other two groups.CONCLUSION:The SLE has extremely significant differenceson gender; women’ sincidence of disease is higher than men. SLE has a significant difference in all age group,higher incidence of young adult, more commonly occurs between the ages of21-40. In the nine kinds of constitutions, mixed constitutions are commonly exist, of which more patients are Qi-deficiency constitution. The Yang-deficiency constitution、 Yin-deficiency constitutionand Impressed constitution, older patients or patients with longer duration of disease are commonly seen in Yang-deficiency constitution. In the treatment option of treating patients from mild to moderate SLE, efficacy and safety are taken into consideration. Thus, we prefer to choose combined hormone and Xiaochaihu decoction for treatment, and apply it according to different patients’constitutions. |
PDF Full Text Request