The Study Of The Correlations Between Henoch-Schonleinpurpura Nephritis And Constitution Of Traditional Chinese MediCine

Object i veDiscussion on distribution regularity of TCM Constitution of Henoch-Schonlein Purpura Nephritis patients, the existence of constitutional predisposition. Discussion The correlation between the occurrence of Henoch-Schonlein purpura nephritis, clinical phenotype, pathological classification and TCM Constitution. To investigate the correlation between the effect of angiotensin converting enzyme (ACE) insertion/deletion polymorphism and the genetic susceptibility of Henoch-Schonlein purpura nephritis, clinical phenotype, pathological grade, TCM Constitution.MethodsFor patients who met inclusion criteria, TCM Constitution questionnaire, collecting the general condition of patients, clinical index, TCM syndrome, pathological classification data. Using modern statistical methods statistical analysis for the above data. Exploring the basic characteristics of different constitution in this disease. By polymerase chain reaction (PCR) detection of Henoch-Schonlein purpura nephritis in patients with ACE gene polymorphism. Combined with the onset of Henoch-Schonlein purpura nephritis, clinical phenotype, pathological classification, constitution of traditional Chinese Medicine. Correlation analysis between them.Results1. Henoch-Schonlein purpura nephritis patients with empty physique majority. The main type of constitution is dry and heat constitution, amount to54cases, accounting for42.86%. Solid body to dull and obscure constitution as much, amount to9cases, accounting for7.14%. That patients with the disease occurred in relatively weak physique.2. There is no significant difference between Henoch-Schonlein purpura nephritis patients age, gender, nationality and type of constitution. But, it exist certain relationship between the seasonal incidence and predisposing factors and type of constitution. Henoch-Schonlein purpura nephritis usually occurres in winter and spring. But the fatigue and trance constitution, greasy and stagnate constitution usually occur in summer and Autumn. After two two more, slow and cold constitution and dry and heat constitution has a significant difference in the incidence of seasonal, slow and cold constitution usually occurs in winter and spring seasons. Greasy and stagnate constitution and dry and heat constitution, slow and cold constitution also have significant differences in the incidence of seasonal. Greasy and stagnate constitution usually occurs in summer and Autumn. There was a significant difference between the group of the constitution of predisposing factors distribution. The dry and heat constitution, slow and cold constitution incentives for food, drugs, when fatigue and trance constitution inducement is cold. The other constitution has no obvious bias.3. TCM constitution types have associated with syndrome of Henoch-Schonlein purpura nephritis.It is high risk factors and important traits of Ilenoch-Schonlein purpura nephr it is. Dry and heat constitution than for patients with internal heat due to yin deficiency, blood stasis syndrome. The fatigue and trance constitution and slow and cold constitution showed spleen qi deficiency, syndrome of Qi failing to control blood.4. Different constitution not only have different clinical symptoms, while also showing clinical objective indexes of different. Dry and heat constitution patients urinary protein was significantly higher than that of fatigue and trance constitution and dull and obscure constitution patients. Greasy and stagnate constitution urinary protein was significantly higher than that of fatigue and trance constitution. Dry and heat constitution cells of patients with urinary red relatively, while fatigue and trance constitution with a minimum quality of red blood cells in urine. The biochemical indexes, in addition to fatigue and trance constitution for the highest triglyceride, others had no statistical significance. In the blood coagulation index, dry and heat constitution in patients with PT was significantly less than slow and cold constitution and obscure quality of patients. There is no significant differences in the immunological indexes.5. Different constitution has different renal pathology, slow and cold constitution patients with pathological grading IV are heavier, pathology, prognosis. Dry and heat constitution patients with pathologic grade II are lighter, pathology, prognosis.6. Genetic DD genotype and D allele may be the pathogenesis of Henoch-Schonlein purpura nephritis susceptibility gene.7. DD genotype and carrying the D allele may increase the probability of a lot of proteinuria in patients with Henoch-Schonlein purpura nephritis. ACE gene polymorphism may independent of Henoch-Schonlein purpura nephritis patients with hematuria. The DI genotype frequency in renal insufficiency group was significantly higher than that in the normal renal function group. But the D and I allele frequencies in the renal dysfunction group and the normal renal function group is no significant differences.8. DD genotype may be a susceptible gene, which Henoch-Schonlein purpura nephritis patients genetic occurrence severe renal pathological damage.9. The Ⅱ gene in the dry and heat constitution patients was significantly higher than that in slow and cold constitution patients. The I allele frequency in the fatigue and trance constitution, slow and cold constitution patients was significantly lower than that of dry and heat constitution patients.Conelusions1. Henoch-Schonlein purpura nephritis patients have constitutional predisposition, the main type of constitution is dry and heat constitution.2. TCM.constitutional types are Henoch-Schonlein purpura nephritis risk factors and important traits, which is related to Henoch-Schonlein purpura nephritis syndrome.3. There is no significant difference between Henoch-Schonlein purpura nephritis patients age, gender, nationality and type of constitution. But, it exist certain relationship between the seasonal incidence, predisposing factors, Clinical and pathological grade.4. Genetic DD genotype and D allele may be the pathogenesis of Henoch-Schonlein purpura nephritis susceptibility gene. Ⅱ genotype may be a protective gene.5. DD genotype may increase the incidence of Henoch-Schonlein purpura nephritis in patients with heavy proteinuria, renal insufficiency, severe renal damage.