Study On The Health Of The Aged And The Relationship Between The Related Chronic Diseases And Insulin Resistance Genes

Objective:Jilin Province entered the aging society in2003, and the degree of aging rapidlyincreasing. The health status of the elderly in particular, Jilin case depth andcomprehensive study of chronic disease is rare. According to the2010StatisticalYearbook of Jilin province, total population of2719.48million, the population agedover60is363.26million, of which over60years in Changchun population was102.67million, ranking first in the province. Siping population aged over60is387900who ranked third in the province. This study analyzed the health of1946theelderly population in Changchun, Siping, providing the basis for decision-makingforward-looking and disease prevention in the elderly population. In order to fullyrational use of limited health resources, satisfy the elderly population health serviceneeds, improve their health and quality of life.Primacy of chronic diseases such as diabetes, hypertension and other majorfactors affect the health of the elderly and are the cause of death. This study is basedon site survey and examination results, choose a higher prevalence of chronic diseasesas diabetes and hypertension as a laboratory study by SNP genotyping experiments,insulin resistance-related genes (adiponectin, leptin receptor, resistin and TRB3)polymorphism and elderly people suffering from type2diabetes and the relationshipbetween essential hypertension for disease prevention, diagnosis and treatment toprovide laboratory data.Insulin resistance plays an important role in the development of type2diabetesmellitus (T2DM) and hypertension. The purpose of the present study was to evaluatethe association between4insulin resistance genes (ADIPOQ, LEPR, RETN, andTRIB3) and both T2DM and hypertension.Methods:1946people over60in Changchun and Siping cities are Stratified by clustersampling method and the combination of extraction, taking questionnaire survey ofhealth status of its investigation. Using Epidata3.0software to build a database with SPSS13.0statistical analysis of the data, measurement data were expressed as mean±standard deviation; count data rate, proportion said. Measurement data were analyzedusing t test, count data using χ2test. Multivariate analysis is used Logistic regressionanalysis. After the survey, the elderly health examination, including measurement anddetection of height, weight, blood pressure, blood sugar, blood lipids, ECG.A total of587Han Chinese subjects were recruited into this study, including188cases who had T2DM alone,223cases who had hypertension alone, and176controlsubjects with neither T2DM nor hypertension. Twenty-three tag SNPs in4insulinresistance genes were genotyped and analyzed for association with T2DM andhypertension.Results:This study health survey of1946elderly people, the maximum age100years,minimum age60years old, more women than men. The old cultural level is low, mostprimary degrees (29.4%). older people of SiPing City living with a spouse is higherthan that of changchun city elderly people (61.5%,47.7%); SiPing City old-ageincome was lower than those of changchun older adults,17.5%of the elderly did notattend any medical insurance; The elderly health behavior situation is not optimistic:smoking rates is21.8%; Every night sleep time is less than7to8hours (38.7%); Likeeating salty the elderly accounted for nearly a third,43.1%don’t often take part inphysical training.The elderly people were investigated with38.6%(752/1946) for the obese,63.0%(1226/1946), dyslipidemia, abnormal ecg30.9%(602/1946); the elderlychronic disease prevalence of Siping (90.8%) was significantly higher thanChangchun (65.8%). The top five prevalences of chronic diseases are in turn forhypertension, heart disease, diabetes, joint disease, cerebrovascular disease; Area,BMI, age are the independent prevalence factors of chronic disease; higher prevalenceof chronic diseases in less developed areas, the greater BMI the greater prevalence ofchronic diseases, higher prevalence of younger than elder;74.3%preferred the elderlyhealth services demand for regular physical examination;51.3%of the elderly are notactive consciousness of access to health care knowledge; The old commonentertainment is single, give priority with TV and walking.One intron SNP (rs13306519) in LEPR and one3′UTR SNP (rs1063537) inADIPOQ demonstrated a significant association with T2DM (P=0.024and0.014respectively). Another intron SNP (rs12037879) in LEPR and a promoter region SNP (rs266729) in ADIPOQ were significantly associated with hypertension (P=0.041and0.042, respectively). After adjusting for gender and age, these associationsremained significant under an additive model (P=0.019,0.018,0.026, and0.046,respectively). These associations did not survive the Bonferroni correction formultiple comparisons (corrected P>0.05). No other gene variants were found to besignificantly associated with T2DM or hypertension (P>0.05). None of the studiedgene variants were found to be significantly associated with T2DM+hypertension (P>0.05).Conclusion:1. Maximum elderly aged100years old, the minimum age of60years, mean age68.33±6.778years; female ratio0.47:1;21.6%were illiterate or semi-literateelderly;15.5%in the elderly do not have any income.2. elderly diet with grains, vegetables and egg-based;56.9%of older peopleexercise regularly, exercise-oriented way of walking;61.8%of older people beingoverweight or obese.3. elderly chronic disease prevalence was78.9%, the prevalence of chronicdiseases among the top five were hypertension, coronary heart disease, diabetes, boneand joint disease, cerebrovascular disease.4. elderly hypertension and diabetes prevalence rates were52.2%,37.2%,hypertension and diabetes prevalence main factors affecting the region, age, bodymass index.5.48.7%of the elderly can take the initiative to get health care knowledge,74.3%of health services elderly want to get a regular physical examination,49.6%ofolder people want to tertiary level hospital.6LEPR SNP (rs13306519) G allele of the ADIPOQ SNP (rs1063537) T allele oftype2diabetes may play an important role; LEPR SNP (rs12037879) A allele,ADIPOQ SNP (rs266729) G allele of primary hypertension may play an importantrole.7. LEPR SNP rs13306519and ADIPOQ SNP rs266729with type2diabetes andhypertension have significant interaction. These two genes variants also carry humanoccurrence or development higher risk than those who only carry a single genemutation.