Clinical Significance Of Determination Of Serum Complement Levels In86Cases With Liver Diseases

The complement system plays an important role in the immune response,while80%of it is synthesized in the liver. The production of complementwill decrease if the liver cells are destroyed. Hepatobiliary surgery ismainly in surgical treatment of hepatocellular carcinoma, intrahepatic bileduct stones, liver cirrhosis and severe hepatitis due to acute or chronicliver failure and other diseases, and the complement system may beinvolved in the pathogenesis of these diseases. Therefore, it has importantclinical significance to determinate the serum complement levels inpatients with liver diseases.ObjectiveTo investigate the clinical significance of the serum complement levels todetection or evaluation of the primary liver cancer, liver cirrhosis andother liver diseases, by collecting and analyzing the relevant clinical dataof86cases who are treated in Hepatobiliary Surgery of our hospital inrecent years and are enrolled into the groups. MethodsCheck the serum complement levels, blood, liver and kidney function,blood clotting routine, AFP values and so on of the patients duringhospitalization, who were treated in Hepatobiliary Surgery of ShanghaiFirst People’s Hospital from January1,2012to December31,2013. Getthe results of their B ultrasound, CT and other imaging inspection. Checkthe serum complement levels, blood, liver and kidney function, bloodclotting routine after the surgery when conditions permitting. Record thepathological grading. Then collect all results to do a statistical analysiscombined with factors of age, gender and so on.Results(1) The serum complement levels in patients with liver disease, has nosignificant correlation with the gender or age.(2) The serum complement levels and blood clotting status interact witheach other. It probably reflects the liver synthetic function. Comparedwith normal control group, the serum C3, C4, CH50of patients with liverdiseases decreased, especially in patients with liver cirrhosis. The levelsdecrease less in C4and patients with liver cancer, and it has nosignificant correlation with AFP, CEA and CA199(3) The levels of serum complement have a certain degree ofdiscrimination significance with the pathology of chronic hepatitis B patients in hepatitis activity grading, pathological staging of liver fibrosis,liver tumor histological type and differentiation.(4) The surgery impacts the levels’ recovery process of serumcomplement in patients with hepatocellular carcinoma after surgery.Compared with patients with liver resection, the levels of C3, C4, CH50of patients with orthotopic liver transplantation delayed. The recovery oflevels of serum complement has no correlation with the status of liverfunction before orthotopic liver transplantation in patients with livercancer.ConclusionIt has had some clinical significance of serum complement levels to theassessment of prognosis, outcome and so on of patients with primary livercancer, liver cirrhosis and other liver diseases.