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System Evaluation Of Therapeutic Effects Of Traditional Chinese Medicine And Quantitative Study On TCM Syndrome Of Internal Rectal Prolapsed

Posted on:2015-09-15Degree:DoctorType:Dissertation
Country:ChinaCandidate:L F CaoFull Text:PDF
GTID:1224330467953503Subject:Traditional surgery
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Purpose: Using statistical methods statistical analysis of traditional Chinese medicinein the treatment of internal rectal prolapse of historical literature, systematic review ofefficacy and safety of traditional Chinese medicine in treatment of internal rectal prolapse.Clinical investigation and four diagnostic indicator of internal rectal prolapse and objectivequantitative, using factor analysis to explore the establishment of TCM syndromes ofinternal rectal prolapse, for clinical reference.Method:1, retrieve journal full-text database in China (CNKI,1989~2012.11),the Chinese biomedical literature database (CBM,1989~2012.11), the Chinese scienceand technology periodical full-text database (VIP,1989~2012.11), doctoral dissertationfull-text database in China (1999~2012.11), China’s outstanding master’s degreedissertation full-text database (1999~2012.11), China important conference papers fulltext data library (2000~2012.11), total retrieved to Chinese literature3,881article, byreading topics early sieve out literature38article, through view full text excludednon-TCM treatment, and non-random, and no controlled and the theory researcharticles, last total into10article research (are for Chinese), will meet conditions ofliterature used RevMan5.0.24software for statistics analysis, evaluation TCM treatmentrectal within off vertical of effect and the security.2, and collection128cases patients offour diagnosis information, preliminary dialectical, came each patients of card waitingtype; then with software Epidata3.1established investigation questionnaire table, willeach patients of four diagnosis information entry, conversion into SPSS database file, abandoned frequency is less than10%of items, for exploration sexual factor analysis,according to maximum may wish to so estimated law extraction factor, get features rootvalue is greater than1.0of public factor has9a, with maximum variance law will factorrotating Hou analysis, get rotating factor matrix. Each factor load factor greater than0.4categorize symptoms and found that some factors reflect the contents match the symptomscharacteristic of traditional Chinese medicine, and finally condensed into4types ofsyndromes, prior to the final and to be compared to the types of symptoms.Results:(1) uses statistics method statistics analysis TCM treatment rectal within offvertical of history literature, last found TCM or integrated Chinese and Western medicinecombines treatment rectal within off vertical of effect obviously is superior to simpleWestern means treatment, has efficiency: RR=1.18,95%CI (1.13,1.24); recovered rate:RR=1.54,95%CI (1.39,1.72), but while also exists many problem:①diagnosis standardof not unified: into of research literature in the diagnosis standard varies, Both nationalindustry Society Conference standards and the national standards set by the relevant units,there are researchers custom diagnostic criteria. Therefore, IRP diagnostic accuracy andaccuracy needs to be improved, which also affected the consistency and repeatability inresearch data.②low methodological quality: assessment of existing standards, themethodological quality of the included studies is generally low, and mainly in the way ofgenerating random sequences is unclear or missing, not obscure group, blinding is notused, distribution, implementation, measurement, statistics, reports, and manyother areas may produce bias exists. Clinical study of low quality may have beenincorporated into the therapeutic effects of Chinese medicines is generally high because ofthe literature. Therefore, significant difference in efficacy between the treatment groupand the control group may be related to low methodological quality of the trials.③lack ofscientific outcome measures: this systematic review using the cure rate,efficient,relapserate and symptom score composite index as a result outcome measures to assess efficacy,lack of uniform standards, scientific and objective enough, and included in the researchliterature on the clinical outcome measures above standards are not consistent, whichcould cause the difference in outcomes.④follow-up and the relapse rate reported rate low:most research indicators measurement selected in intervention ended Hou immediately for, only minority research reported has follow-up Hou effect comparison, and rarelyresearch reported relapse situation or related information enough detailed hard, so thisevaluation has efficiency, and recovered rate indicators are used treatment Hou of instantindicators, is not on long-term follow-up Hou indicators for evaluation, so, neededfurther track observation.⑤study on adverse reactions and economic indices lack: thesystem in the studies included in the review were only2articles on the security problems,but are not specifically described and recorded, so the safety of traditional Chinesemedicine remains to be verified. None of the included studies describes the economicindicators, research on herbal health economics indicators needs to be strengthened.⑥No full show TCM of dialectical on the treatment of advantages: according to TCM partycard corresponding of theory, a prescription (or treatment law) only for withcorresponding of TCM card type Shi to full played prescription (or treatment law) ofeffect, only1a research on rectal within off vertical of treatment for has TCM pointstype, description has research object belongs of TCM card type, remaining research areis not description research object specific of TCM card type, just General of profile forvirtual card, makes evidence of applies range is fuzzy, thereby cannot obtained better ofauthenticity.(2) patients through the four diagnostic analysis of dialectical reached roughly sixtypes of syndromes: intestinal and stagnation type21cases of subsidence, and Qi-27cases,13cases of spleen-kidney Yang-deficiency type,hot and humid place bets-7,badtemper weakness of30cases,30cases of intestine dryness due to Yin deficiency type.Factors in exploratory data analysis using SPSS software, are three syndromes types:①Yin deficiency inner heatDialectical elements: two zygomatic flush, lumbar debility, and five hot, hotflashes, night sweats, irritability, dry mouth, my throat tongue red, fine Moss withless or without Moss, pulse, and so on.②spleen deficiency qi prostrationDialectical point: pale facial expression, myasthenia of limbs, asthenia qi anddistinclination to talk,spontaneously sweat, lips colored light, limb weakness,dizziness, anorexia, tongue pale white, white fur, thin weak pulse, and so on. ③Yang deficiency of spleen and kidneyDialectical point: chills cold extremities,hand,not temperature,body weight loss,teeth shaking, chest tightness, heart palpitations, tongue tongue pale white and edgeshave teeth marks, Moss ’ run, pulse Shen.From the comparison of two methods there are3types of syndrome of the same,using SPSS software in factor of syndrome types in exploratory data analysis of results oftwo less, which can occur for the following reasons:①through dialectical analysis of the four diagnostic information in patients withartificial subjective, is the so-called subjective, clue has already given for the samepatients, different types of doctor may conclude that the syndrome is not the same, andtherefore concluded that the results are biased. Using software to analyze are objectivity,so results will have a certain amount of difference.②as the survey sample size of only128cases, relatively small sample size, it mayreceive the above error.③hot and humid place bets type cases with fewer, smaller proportion, at theexpense of frequency smaller signs project has been abandoned when,in factor analysis isnot parsed.④intestinal stagnation type of cases number about accounted for total samplesvolume of16.4%, but in data statistics in the is is not appeared, from statistics data see,representative intestinal stagnation type of belching due to frequency is less than10%haswas abandoned, bloating abdominal pain total of frequency for87.5%, and intestinalstagnation type only accounted for to16.4%, not has representative, breast distendingpain in only accounted for11.7%, just over10%of abandoned line, share smaller, andsimple of tongue pulse and cannot determines a a card type, Intestinal-stagnation, nostatistical analysis is therefore granted.Conclusions: this study uses statistics method statistics analysis TCM treatment rectalwithin off vertical of history literature, system evaluation TCM treatment rectal within offvertical of effect and the security, thereby found has currently TCM treatment rectalwithin off vertical performance out of problem, and through clinical investigation willrectal within off vertical of four diagnosis indicators objective quantitative, established a relative specification of rectal within off vertical card waiting of diagnosis standard,to forclinical reference.
Keywords/Search Tags:internal rectal prolapse, constipation caused by outlet obstruction, medicine, systematic reviews, TCM symptoms, Meta analysis, factor analysis
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