Study On The Underlying Mechanism Of Liver-qi Depressed Dispersedness-the Location Of Brain Research On Liver-qi Depression Of Premenstrual Syndrome

Objectives: The incidence of emotional diseases which impact on people’s quality oflife and work status are increasing day by day. Therefore, this study leads to research onthe brain location of Liver-qi Depression of PMS.To explore the brain location of “liverregulating the normal flow of Qi and emotions”.Methods:The BOLD-functional magnetic resonance imaging (fMRI) was used in thisresearch.Case group of PMS patients complyed with the American Society of Obstetricsand Gynecology (ACOG) international diagnostic criteria.Also they complyed withdiagnostic criteria of Liver-qi Depression.Control group subjects were healthy whomatched age, sex and education with case group.All subjects viewed pictures whichcould induce depression in the process of functional magnetic resonance scanning.SPM8software and t test were used to analyse the fMRI data.Results:13subjects were recruited in case group.15subjects were recruited in controlgroup.All subjects who were no differences in age, sex and education were students ofShandong University of Traditional Chinese Medicine. Subjects completed all tasks inaccordance with the scan.Data collected was all effective.Resting state: Case group brain areas activation enhanced compared with controlgroup: Sub-lobar,Extra-Nuclear,Frontal_Mid_L (aal),Frontal_Inf_Tri_L (aal),Frontal_Sup_L (aal), Brodmann area8,Frontal_Sup_Medial_L (aal),Frontal_Inf_Orb_L(aal), Brodmann area9,Frontal_Inf_Oper_L (aal),Frontal_Sup_Orb_L (aal), Brodmannarea47, Brodmann area32,Frontal_Mid_R (aal), Brodmann area6,Frontal_Sup_R(aal), Frontal_Inf_Tri_R(aal), Brodmann area11, Frontal_Sup_Medial_R(aal),Frontal_Inf_Oper_R (aal),Caudate_L (aal),Insula_L (aal),Insular cortex,Amygdala, Hippocampus,Putamen_L (aal),Corpus Callosum,Caudate Body,Caudate Head,Thalamus_L (aal),Lateral Globus Pallidus,Claustrum,Medial Globus Pallidus, Caudate_R(aal), Pallidum_L (aal),Thalamus_R (aal),Cingulum_Mid_L (aal).Tasking state: Case group brain areas were activated enhanced in task negativeemotion pictures: Precentral_L (aal)，Brodmann area6, Frontal_Inf_Oper_R (aal),Brodmann area7,Postcentral_R (aal), SupraMarginal_L (aal), Inferior Parietal Lobule,Postcentral_L (aal), Brodmann area40, PreCuneus_R (aal), Brodmann area31, PreCuneus_L(aal), Occipital_Sup_L (aal), Calcarine_L (aal), Cuneus_L (aal), Cuneus_R (aal),Calcarine_R (aal), Occipital_Sup_R (aal), Brodmann area19, Brodmann area18,Temporal_Sup_R(aal), Rolandic_Oper_R (aal), Temporal_Mid_R(aal),Temporal_Pole_Sup_R (aal),Heschl_R (aal), Frontal-Temporal Space, Brodmann area30,Temporal_Sup_L (aal), Heschl_L (aal), Brodmann area41,Temporal_Mid_L (aal),Brodmann area22,Insula_R (aal), Brodmann area13, Insula_L (aal),Brodmann area43.Case group brain areas activation enhanced compared with control group in task:Occipital_Inf_R (aal), Brodmann area18, Brodmann area19, Occipital_Mid_R (aal),Lingual_R (aal), Fusiform_R (aal), Brodmann area37, Temporal_Inf_R (aal),Cerebelum_Crus1_R, Culmen, Cerebellum Anterior Lobe, Tuber, Cerebellar Tonsil. Casegroup brain areas activation decreased compared with control group in task:Frontal_Sup_Orb_L (aal), Frontal_Mid_R (aal), Brodmann area10, Brodmann area11,Rectus_L (aal), Rectus_R (aal), Brodmann area47, Brodmann area46, Brodmann area32,Brodmann area25, Insula_R (aal), Amygdala, Hippocampus, Cingulum_Ant_L (aal),Cingulum_Ant_R (aal), Caudate_L (aal), Caudate Head, Putamen, Caudate_R (aal),Putamen_L (aal),Putamen_R (aal),Pallidum_L (aal).Case group compared with controlgroup in task, Occipital Lobe,Temporal Lobe, Cerebellum were activated enhanced,Sub-lobar,Sub-Gyral,Extra-Nuclear, Frontal Lobe,Limbic Lobe were activated declined.Conclusions:1.The main regulatory brain areas of Liver-qi Depression ofPremenstrual syndrome:Frontal Lobe, Temporal Lobe, bilateral Precuneus,Occipital,posterior Cingulate Cortex, bilateral Insula.2.Pathogenesis of central mechanisms about Liver-qi Depression of Premenstrualsyndrome: Occipital Lobe, Temporal Lobe, Cerebellum activated enhanced;Sub-lobar，Sub-Gyral， Extra-Nuclear,Frontal Lobe(Orbitofrontal cortex, Frontal medial surfacespecially),Limbic Lobe,Cingulate Gyrus,Basal Nuclei activated declined.3. We have explared liver regulating emotons of brain areas: Frontal Lobe，Parietal Lobe, Occipital Lobe, bilateral Insula, Cingulate Cortex.