Study Of LDCT Screening Program For Lung Cancer In Health Promotion Center

Background:Lung cancer is the leading cause of cancer death in the United States and worldwide. How to detect lung cancer in early stage is an important issue for medical experts. In June,2011, findings from the National Cancer Institute’s National Lung Screening Trial established that lung cancer mortality in specific high risk groups can be reduced about 20% by annual screening with low-dose computed tomography. It is the greatest news in this area. But many questions remain when we seek to understand the implications of the NLST. Are the NLST results suitable to other patient populations? At what age should screening begin, and for how many years should it continue? What’s more, there are many concerns about LDCT include false positive results, overdiagnosis, radiation exposure, and cost effectiveness. International debate is ongoing about whether sufficient evidence exists to implement CT screening programs.Objective:The purpose of this study is to evaluate the practice condition of low dose CT screening lung cancer program in health promotion center in Sir Run Run Shaw Hospital, and help the health promotion center in China and physicians to practice lung cancer screening program more reasonable.Methods:collect all the data of LDCT lung cancer screening program in Sir Run Run Shaw Hospital in Past ten years. The prevalence of nodules, the prevalence of lung cancer, cost effectiveness, the relationship between lung cancer and age, gender, biochemical items, tumor markers were analyzed. LDCT group and X-ray group were compared.Results:A total of 13997 subjects (8956 male and 5041 female) aged 48.13±9.85 were selected from those who underwent lung cancer screening in our hospital in past ten years. Nodules were found in 4612 subjects and lung cancer was found in 18 subjects, the ratio is 33% and 1.3%o respectively. The false positive ratio of lung nodules is 99%. The prevalence of lung cancer is associated with age (P value <0.001), the highest one is 5.19%o in elder than 70 years old group, then 3.86%o in 60-70 years old group.36083 subjects were enrolled in x-ray group. Nodules were found in 788 subjects and only one case with lung cancer. In 18 lung cancer cases, there are 12 males and 6 females. There are 12 adenomas,1 squamous cell cancer and 2 small lung cancers, 3 of them are undefined. Most of them are stage I lung cancer.Conclusions:LDCT can be used as a lung cancer screening technique, but the ratio of positive lung cancer is low. Stage I cancers can be detected in LDCT group, which is a great benefit. If we can take age and smoking condition into account for selecting lung cancer screening population, the positive lung cancer ratio will improved.