The Clinical Experience Of The Academic Thought Of Professor Gan Aiping Spleen And Stomach Disease And The Clinical Experience Of Diagnosis And Treatment Of Functional Dyspepsia

BackgroundThe clinical experience and academic thought of Famous old doctor of Traditional Chinese medicine(TCM) is the source of innovation and development of TCM.To study the academic thought and the clinical experience of famous old doctor of TCM has also become one of the hot spot of current research of TCM. In recent years,data mining is the rise of computing technology and method which can reveal the laws of medicine formula of the famous doctor, from a large number of incomplete noisy fuzzy random data, extracting potentially useful information and knowledge in which people do not know in advance. TCM inheritance auxiliary platform software(version 2.0) has a famous doctor basis finishing prescription prescription screening and discovery of new drug of TCM formula drug law analysis such as powerful function. Based on the software, it can form set data acquisition, data storage, data analysis and data services in the integration of inheritance of TCM scientific research platform, realizes the function of data entry-management-query-analysis.As a famous TCM doctor of Hubei Province and Wuhan City, fifthnational old TCM experts in the academic inheriting experience of the instructor, professor Gan Aiping has rich experience of prevention and treatment of spleen and stomach disease of TCM and geriatrics, especially for functional dyspepsia(FD) and other functional gastrointestinal disease has a unique understanding. As a clinical common diseases frequently occurring, FD is an upward trend in the incidence of a disease. Because of the characteristics of recurrent in delay refractory and hospitalized repeatedly, FD consume large amounts of medical resources. TCM in the diagnosis and treatment of FD has certain advantages. By means of TCM inheritance auxiliary platform software, we carry out systemly research professor Gan Aiping’s academic ideas and the experience of treatment of FD, adopting the method of combination of retrospective and prospective research.ObjectiveThis paper’s objective is summarize professor Gan Aiping’s academic thoughts and clinical experience of treating FD systemly,mining professor Gan Aiping’s academic thought, unique treatment methods and prescription medication rule, in order to carry on the inheritance and innovation of TCM betterly, explore the features and advantages of the treatment of spleen and stomach disease with TCM, improveing the clinical curative effect of TCM in the treatment of FD.MethodsMethod one: Extraction of ancient physicians about the theory of spleen and stomach theory and view through repeated readings the classic medical books professor Gan Aiping recommended, such as“the Yellow Emperor”,“Treatise on Cold Damage and MiscellaneousDiseases”, “Treatise on Spleen and Stomach”, “Warm Disease the Cause” and“a Guide to Clinical Practice with Medical Records”.Extraction of the major spleen and stomach academic thoughts and opinions of professor Wei Xibao, by collecting professor Wei Xibao of scientific research and experience. collect the thesis with teacher Wei Xibao, master thesis writing, notes of professor Gan Aiping and biconditional gate disciple. By collecting professor Gan Aiping published or unpublished writings, books, scientific research projects,lecture notes and graduation thesis of her students, professor Gan Aiping’s main spleen and stomach diagnosis and treatment experience of academic thought academic views can be summarized.Method two: By collecting professor Gan Aiping written papers on FD, graduation thesis papers of Gan Aiping’s students, thesis of month written, notes,medical cases, etc., combining the guidance and the clinic experience of professor Gan Aiping, the following experiences of professor Gan Aiping on FD can be summarized, such as the etiology and pathogenesis, four diagnostic features,syndrome differentiation system and TCM drugs experience.Method three: 376 cases of FD patients are collected from Hubei Province Hospital of TCM, diagnosed by professor Gan Aiping. Fill in the patient’s general information(name Age and gender) and symptoms coating on the tongue pulse condition of TCM syndrome type of prescription medication, fill in the Gastrointestinal Diseases of TCM Symptom Scale(2011 edition), all the above information will be input of auxiliary platform acquisition system module. Through the statistics of the cases, we can statistic for patient information, syndrome, symptoms, drugs frequency statistics,sexual flavour, Drug usage. Through the data analysis module basis analysis under the function of syndrome, we can analysis symptom sorting, symptoms regularity and symptoms clustering analysis.Through the data analysis of prescription and syndrome analysis,we can statistical analysis the key drugs and symptoms by network show.ResultsPart 1: Academic thoughts research of professor Gan Aiping spleen and stomachThe formation of academic thoughts of professor Gan Aiping influenced not only by the second batch of old chinese medicine expert professor Wei Xibao, but also by the medical classic of “the Yellow Emperor”,“Treatise on Cold Damage and Miscellaneous Diseases”, “Treatise on Spleen and Stomach”, “Warm Disease the Cause” and“a Guide to Clinical Practice with Medical Records.“The Yellow Emperor” of spleen and stomach physiology pathology,treatment and prognosis, etc., this paper laid the groundwork for the formation of the theory of spleen and stomach. As Zhang Zhongjing’s significant academic thoughts, the theorys of“Four Seasons Spleen Flourishing from Evil Spleen and Stomach”,“Spleen and Stomach Separately Treatment” and “Protecting Stomach Qi and Body Fluid”And prescriptions of Xie Xin soup of samba open and bitter drop to lay the basis for the clinical practice of spleen and stomach theory. Because of the academic thoughts of“Internal Injuries Spleen and Stomach, Cause All Illness”proposed by Li Dongyuan and the views of “Spleen and Stomach Qi Theory”, “Spleen Rise and Stomach Fall Theory”and “the Theory of Spleen Yin Theory”, Li Dongyuan founded the theory of spleenand stomach, be putty send representative subject. In the qing dynasty, Ye Tianshi “Stomach Yin theory” and “a Long Illness into the Network Theory” are put forward to the chronic disease of spleen and stomach, and old age has important guiding significance of diagnosis and treatment of spleen and stomach disease, enrich and perfect the content of the academic thoughs. Wei Xibao old doctor of TCM, as a teacher of professor Gan Aiping, attaches great importance to the rise and fall of Qi activity, drop stomach Qi,balance the zang-fu organs, regulating liver Qi and spleen Qi,scrutinize pathogenesis and releasing lungs Qi. Professor Wei Xibao“regulate qi activity first”academic thought has direct influence to the formation of professor Gan Anping“spleen and stomach is fundamental, regulating Qi first”idea. Professor Gan Aiping’s main academic thought is“spleen and stomach in the five zang-organs integration view”. The main ideas include“spleen and stomach is fundamental, adjustable Qi first”,“ Balance the five zang-organs, invigorating therapy combined with dispersing therapy”,“coordination of Yin and Yang, prevention and treatment integrated”,etc. Adhering to the TCM thought of “do not treat has been disease”, professor Gan Aiping emphasize prevention first and combining prevention and treatment. Deficiency and excess syndrome of chronic gastrointestinal diseases is many, purely empirical or deficiency syndrome is less. The principle of treatment is“balancing internal organs”, “reinforcing method and reducing simultaneously”, not biased either party. In regulating Qi activity, professor Gan Aiping treat FD “supplementing spleen Qi”and “Down the stomach Qi”at the same time, do not forgetting to“relief liver for smooth Qi” and “ventilating lung Qi”. Inthe diagnosis and treatment experience, professor Gan Aiping emphasizes four arguments, the diet and modern, especially tongue diagnosis.Part 2: The empirical research of professor Gan Aiping diagnosis and treatment of FD1. For FD pathogenesis, Professor Gan Aiping think that Spleen deficiency is the basis of functional dyspepsia. Disorder of Qi activity is the key to the pathogenesis of FD. Eating is the source of onset modern internal injuries is difficult to conquer.2. On the treatment experience, professor Gan Aiping Think that regulate Qi activity is the basic solution in the treatment of FD.Supplementing Qi and nourishing Yin, Clearing Heat and Wet,resolveing depression is also important for treating FD. The methods of regulating Qi activity of lung Qi, spleen and stomach Qi and liver Qi is different.3. On the experience, professor Gan Aiping often use the treatment based on FD parting disease drugs combined Card type,syndrome and syndrome differentiation. Professor Gan Aiping divide FD into liver stomach disharmony syndrome, liver stagnation and spleen deficiency, spleen and stomach hot and humid, spleen and stomach cold and heat mixed cards, spleen and stomach deficiency and cold, etc., were given to Xin Wei soup, Si Jun Zi decoction and Xiangsha Zhi Zhu pill, Lian Pu drink, Ban Xia Xie Xin Decoction, Li Zhong pill in the treatment, etc.4. On the disease medication, depending on the combination of disease, professor Gan Aiping take different treatment. On FD combined chronic gastritis, depending on the spleen and stomach hot and humid, the spleen deficient and Qi stagnation, liver fireinvading the stomach and stomach Yin deficiency such as different selection skullcap, choose Fritillaria, Atractylodes, Chinese yam,turmeric, Amomum, littoralis, habitat, etc.As with constipation,according to the card type selection of different experience party Tiao Chang soup or Zhi Shi Dao Chi pills, Dan Zhi Xiao Yao San oral, or the experience of Wei Chang Shu liquor enema. Such as merger,diarrhea belongs to Qi deficiency, with Additive Shen Ling Bai Zhu decoction. Will accordingly, with Bu Zhong Yiqi TAng. Long drain injured Yin to reducing, with YIWei Decoction. Hot and humid, with effective to tonga. Liver stagnation and spleen deficiency, with modified Tongxie Yaofang; Spleen and kidney Yang deficiency, with Four Gods pill to add and subtract; Helicobacter pylori infection,with Dandelion, Scutellaria, Coptis, honeysuckle, Houttuynia,Oldenlandia, paeonol, chrysanthemum etc.; Aanxiety depression,professor Gan Aiping differentiation according to six depressive illness, with Xiang Sha Liu Jun Zi soup, Yue Ju pill, Dan Zhi Xiao Yao San or Suan Zao Ren soup add and subtract.5. Professor Gan Aiping treatment for the diagnosis of pain,often choose corydalis, calcined corrugated son, white peony root,etc.; epigastric pain choose peony, atractylodes, chinese yam,Poria,etc.; acid reflux choose Gualou, citrus aurantium,fritillaria, Zhuru, almonds, etc.; constipation choose atractylodes, astragalus, citrus aurantium, Yuli, almonds, etc.;irritability, insomnia is the choice of silk tree flower, roses,Bupleurum, turmeric, lily, Caulis like; an increase in the number of fecal, choose fried atractylodes, wind, dandelion, gall, white peony root; mucus pus and blood will choose seven powder, dandelion,grass snake tongue, houttuynia, sargentgloryvi, patrinia, skullcap,berberine and so on.Part 3: The research of the regularlation of professor Gan Aiping Treating FD based on the inheritance of TCM auxiliary system.Diagnosis and treatment of 376 cases of FD professor Gan Aiping of medical case results are as follows:1. Symptoms statistics show that ranked in the top 10 with functional dyspepsia symptoms were: epigastric fullness(116times), dry mouth(78 times), belching(57 times), insomnia(55times), mouth Bitter(52 times), acid reflux(51 times), abdominal distension(38 times), epigastric pain(32 times), heartburn(31times), fatigue(31 times).2. Disease statistics show that, with FD merging diseases are:“Fullness”, “stomach pain”,“depressive”,“epigastric noise”,“acid reflux”,“constipation”,“Mei He gas”,“dirty impetuous”,“diarrhea”and “cough”.3. Syndromes statistics show that, professor Gan Aiping syndrome often witness type of functional dyspepsia show that,Spleen deficiency syndrome(82 times), stomach heat syndrome(81times), liver depression and Qi stagnation syndrome(71 times),taste hot and humid(69 times), liver depression spleen deficiency Qi and Yin deficiency(56 times), spleen deficiency cold syndrome(19 times), liver stomach with card(16 times), Yin deficiency and internal(13 times), stomach Yin deficiency syndrome(8times).4. Therapeutic principle statistics of Professor Gan Aiping treatment of main treatment methods for FD show that, supplementing qi and invigorating spleen(82times), Clearing heat to reconcile the stomach(81 times)、dispelling stomach-heat(81 times),clearingheat and dissipating dampness(73times)、relief liver for smooth Qi(71times),supplementing spleen Qi and regulating the liver-Qi(60times), regulating stomach and removing painful abdominal mass(35times),nourishing Yin for moistening dryness(29times),reinforcing Qi and nourishing Yin(29 times)、regulating the liver-Qi(25 times)。5. Drug statistics, Professor Gan Aiping therapy FD of the main drug of turmeric(351 times), Poria(Poria, Poria skin)(350 times),Fritillaria(343 times), Atractylodes(Atractylodes, fried Atractylodes)(338 times), peony(peony, red peony)(319 times),Lily(290 times), Amomum(258 times), Albizia julibrissin(skin)(254), Rose(254 times), Yuzhu(248 times), bergamot(244 times),white and(227 times), dandelion(223 times).6. Prodrug classified information 20 points flavor as follows:Rutaceae(696 times), Liliaceae(684 times), ginger family(622times), Asteraceae(408 times), Blanco(401 times), buttercup Section(386 times), Rosaceae(385 times), Gramineae(310 times),legumes(304 times), Polyporaceae(295 times).7. Four gas drugs classified display: cold(1725 times),temperature(1716 times), cool(1457 times), level(1026 times),heat(3 times).8. The drug information flavors are: bitter(3527times), Gan(3401times), Xin(1647times), acid(882times), astringent(410times), light(347times), salty(84times).9. The drug information of drug-Meridian are : lung(3138 times),liver(719 times), spleen(2393 times), stomach(2334 times), heart(1509 times), kidney(1131 times), colon(357 times), gall bladder(243 times), small intestine(107 times), bladder(62 times),triple burner(30 times), pericardium(19 times).10. The composition of drug law show: 2 groups of drugs in combination with turmeric, Fritillaria; lily, Amomum; lily,turmeric; lily, Fritillaria; turmeric, Poria based. 3 groups of drugs in combination with lilies, turmeric, Amomum; lily, Amomum,Fritillaria; lily, turmeric, Fritillaria; lily, bergamot, Amomum;lily, bergamot, turmeric. 4 groups of drugs in combination with lilies, turmeric, Amomum, Fritillaria; lily, bergamot, turmeric,Amomum; lily, bergamot, Amomum, citron; lily, bergamot, Amomum,Fritillaria; lilies, roses, turmeric, Amomum based.Turmeric,Amomum, Poria, Atractylodes, Fritillaria, lily, rose, bergamot,citron, Trichosanthes and so is the heart medication.11. Drug usage analysis show: turmeric, Poria, Fritillaria,Atractylodes, peony, lily, bergamot, Amomum, Albizia julibrissin,rose usual doses of 10 g, 15 g, 15 g, 15 g, 10 g, 15 g, 10 g, 10 g, 10 g,10g.12. The number of 16 to 18 Smell Taste-based; with turmeric,Poria, Radix paeoniae, Fritillaria, Radix paeoniae Rubra, for example, occur most frequently Smell rates were 4.3%, 6.2%, 4.3%,6.1% 4.4%.Conclusion1. Professor Gan Aiping’s main academic thought is “spleen and stomach in the five zang-organs integration view”. The main ideas include“regulate spleen and stomach is fundamental, adjustable Qi first”,“Balance the five zang-organs, invigorating therapy combined with dispersing therapy”and “Coordination of Yin and Yang, prevention and treatment integrated”,etc.2. The formation of academic thoughts of professor Gan Aipinginfluenced not only by the second batch of old Chinese medicine expert professor Wei Xibao, but also by the medical classic of the yellow emperor,Treatise on Cold Damage and Miscellaneous Diseases,Treatise on Spleen and Stomach,Warm disease the cause.3. The understanding of FD’s pathogenesis are: Spleen deficiency is fundamental, Qi imbalance is the key(temper, Stomach,liver, lung disorders), diet is the source of onset, the emotional injuries is intractable due.4. The rule of Professor Gan Aiping treatment of FD is: Regulate Qi activity is professor Gan Aiping’s fundamental solution for the treatment of functional dyspepsia.Supplementing Qi and nourishing Yin, clearing heat and dissipating dampness,relieving the depressed liver is also professor Gan Aiping’s important treatment method for the treatment of FD.5. Professor Gan Aiping’s clinical experience is: in the emphasis on diet and modern internal injuries cause; Emphasis on tongue diagnosis. Invigorating Qi and strengthening spleen,nourishing yin and clearing heat, and the evacuation of liver Qi stagnation are the commonly used methods for treatment FD by professor Gan Aiping. The characteristic of drugs use by professor Gan Aiping is “taste sweet, flat and light”and“medicine and food to fill”.6. FD with epigastric fullness as the main symptom, often accompanied by dry mouth, belching, acid reflux, bloating, insomnia,bitter taste in mouth, epigastric pain, heartburn, uncomfortable evacuation TCM more attributable to the“fullness”category. FD is a syndrome of deficiency and real. Syndromes more deficiency is mixed, with spleen Qi-deficiency, stomach Yin-based, real is mixedwith stomach-heat, Spleen and stomach wet and heat syndrome, heatic depression syndrome dominated. Clearing heat to reconcile the Stomach, replenishing gas and spleen, relieving the depressed liver,clearing heat and dampness are the basic methods of treatment of FD.The main drug therapy with turmeric, Poria, Fritillaria,Atractylodes, peony, lily, Amomum, Albizia julibrissin, roses,Yuzhu based. The medication characteristics of professor Gan Aiping is “Medication calm”, “cold temperature and use”, “Acrid bitter drop”. Making formula plain, therapy combined cooling and warming, pungent drugs can disperse and bitter drugs can descend.FD from “lung”and “liver”of governance is professor Gan Aiping’s characteristics.