Preparation The Drug Delivery Systems Via RAFT Polymerization

“Core-Shell” micelle as drug/gene delivery systems have gained more and moreattention in research area. With crosslinking method, it is easy to overcome theshortcoming of the self-assembled micelles and get stable cross-linked micelles. Theaim of this thesis is to investigate the applicability of polymeric nano-particlessynthesized via reversible addition fragmentation chain transfer (RAFT)polymerization that can be used for the drug delivery of albendazole (ABZ) andHeparin(HP).To achieve this aim, a wide range of polymeric micelle systems based onamphiphilic block copolymers has been synthesized and investigated. Thebiocompatible poly(ethylene glycol) methyl ether methacrylate was chosen to formthe hydrophilic block. Based on the crosslinking techniques, p-nitrophenyl acrylatewas chosen to build the hydropobic block and the functional part. Poly(-caprolactone) was chosen to build another hydrophobic block as it demonstrated toachieve the highest compatibility with the ABZ. To stabilize the structure of micelles,nexus-crosslinking were employed.To further study the efficiency of the drug delivery system, polymer/heparincomplexes have been made and showed enhanced cell uptake ability with theincreasing positive block part. The cytotoxicity assay showed the polymer/heparincomplexes presented little effect on cell viability. In-vitro studies revealed thepromising results of those polymer/heparin complex to be used as drugdelivey systemfor lymphoma treatment.