Synthesis Of Enviroment-Sensitive Hydrogels Based On Cellulose In LiCl/DMAc Solution

Cellulose is the most abundant organic raw material. This inexpensive, biodegradableand renewable resource has received a great deal of attention for its physical properties andchemical reactivity. Many properties of cellulose, both physical and chemical are significantlydifferent from those of synthetic polymers. Therefore, cellulose and cellulose derivatives findapplications in areas as diverse as composite materials, tissue engineering scaffold, drugdelivery systems and personal care products. However, the unique physical properties ofenvironmentally sensitive hydrogels based on cellulose have sparked particular interest intheir applications. As a result, hydrogels are commonly used in tissue engineering, drugdelivery, diagnostics, and cellular immobilization, separation of biomolecules and adsorptionof heavy metals.In this work, a series of cellulose based hydrogels were synthesized in LiCl/DMAcsolution.1. A new kind SIPN cellulose hydrogel was synthesized using NIPAAm and cellulose.The swelling behaviors and temperature sensitivities of the hydrogel were researched in detail.It was found that the swelling ratios of the hydrogels decreased with increasing temperature.The adsorption and release behavior of the hydrogel for cationic methylene blue wasinvestigated. The morphology, thermal behavior and thermal stability of the hydrogel werestudied by SEM, DSC and TGA.2. A big molecular initiator was synthesized by using cellulose and BiBB. Then thecellulose-PNIPAAm-PEGDMA was synthesized by ATRP. Lastly prepared the cellulose basedhydrogel using the cellulose grafted polymer. The swelling behaviors and temperaturesensitivities of the hydrogel were researched in detail. It was found that the LCST of thehydrogel increased with increasing BiBB.3. A pH sensitive cellulose hydrogel was synthesized. The structure and morphology ofthe hydrogel were analyzed by FTIR and SEM. The prepared hydrogel beads showed goodadsorption ability for heavy metal ions.4. A pH and thermal double sensitive cellulose based hydrogel was prepared. Thestructure and morphology of the hydrogel were analyzed by FTIR and SEM. The drug releasebehavior was investigated through model calculations and analysis, combined with the resultsof experiments.