Caorolactam Extraction And Ofloxacin Enantiomers Enantioseparation Using Ionic Liquid

Most organic and inorganic substances have good solubilities in ionic liquids. Since ionic liquids have the properties of low vapor pressure as well as volatility and usually exist as liquid form at room temperature, they have already been used in extracting aromatic organics, such as benzene, phenol, from water. Studies of using ionic liquids in separating nonaromatic organics or substances with high value are little performed at present. In this study, ionic liquids are used to separate caprolactam and ofloxacin enantiomers, respectively, to increase the distribution ratio, enantioselectivity, and decrease the cost of energy and extractant during the extraction process.The main contents are as follows:1.1-butyl-3-methy-limidazolium hexa-fluorophosphate,1-hexyl-3-methy-limidazolium hexa-fluorophosphate,1-octyl-3-methy-limidazolium hexa-fluorophosphate,1-butyl-3-methy-limidazolium bis[(trifluoromethyl)sulfonyl]imide and1-hexyl-3-methy-limidazolium tetrafluoroborate have been used to extract caprolactam from water, respectively. The distribution ratios of caprolactam under different operating conditions have been measured. The effects of structure of ionic liquids, extraction temperature and concentration of ammonium sulfate solution have been investigated. A model has been developed to correlate the obtained experimental data.2. Dibenzoyl-tartaric and chiral ionic liquid1-ethyl-3-methylimidazolium L-tartrate acid have been used as chiral selectors to separate ofloxacin enantiomers. The effects of concentration of [Emim][Ta] in water, concentration of DBTA in decanol, concentration of ofloxacin enantiomers, pH in aqueous phase and temperature have been investigated, respectively. Under certain operating condition, the enantioselectivity can reach3.6, which is larger than the value when using co-extrants. 3. In order to decrease the negative effect of viscosity of ionic liquids in extraction, ionic liquids1-butyl-3-methylimidazolium hexafluorophosphate have been encapsulated into polymer to form microcapsules using microtube extrusion and solvent evaporation methods. The effects of shell material, diameter of microtube, concentration of ionic liquid in oil phase, concentration of gelatin in aqueous phase and stirring speed have been investigated.4. Polysulfone microcapsules containing ionic liquid1-butyl-3-methylimidazolium hexafluorophosphate as extractant have been successfully prepared using solvent evaporation method and used in removing caprolactam from water. The extraction performances of shell material polysulfone and ionic liquid have been studied, respectively. The effects of ammonium sulfate concentration and temperature have been investigated. The kinetic model and adsorption isotherm model have been used to correlate the experiment data.