| BackgroundTakayasu arteritis is a chronic vasculitis that affects primarily large elastic arteries such as the aorta, its main branches, and the pulmonary arteries. The mechanism of Takayasu arteritis is unclear. Many studies have found that many factor have been involved in the pathophysiology of Takayasu arteritis, including age, gender, area, autoimmunity, enviroment, heredity, inflammation and endocrining. RANTES is a muliti-functional chemokine. Many studies have reported that RANTES is associated with atherosclerosis, diabetes, asthma, automimmunal diseases and variuous tumor, that displays potent and selective. The polymorphysm of RANTES gene have been found to be relevant with many inflammation and immune diseases. RANTES concentrations were remarkably higher than normal in the serum of all patients with Takayasu arteritis studied during an active phase of the disease. RANTES serum levels tended to normalize in remission, but values remained significantly higher than in control subjects. Till now, there was no availble studies which have explore the association of RANTES-403G/A and-28C/G gene polymorphysm with the risk of Takayasu arteritis.So we try to explore the association of RANTES-403G/A and-28C/G gene polymorphysm with the risk of Takayasu arteritis in Han population.MethodsWe used a case-control study to assess the relationship between RANTES-403G/A and-28C/G gene polymorphysm and the risk of Takayasu arteritis. TaqMan scope was used to exlpore the genotype.ResultsFor the RANTES-403G/A, the odds ratio (OR) and their corresponding95%confidence interval (CI) was1.515(1.065to2.156, P=0.021);1.499(1.136to1.978; P=0.004);2.305(1.192to4.455, P=0.013)in dominant model, addictive model and recessive model when we did not adjust the relevant risk factors; the OR and95%CI was1.593(1.101to2.305, P=0.014);1.568(1.174to2.096, P=0.002);2.474 (1.253to4.884, P=0.009) in dominant model, addictive model and recessive model when we adjusted the relevant risk factors. For the RANTES-28C/G, the OR and95%CI was1.776,(1.171to2.693, P=0.007);1.742,(1.254to2.420, P=0.001);2.510(1.053to5.984, P=0.038) in dominant model, addictive model and recessive model when we did not adjust the relevant risk factors; the OR and95%CI was1.929,(1.249to2.978, P=0.003);1.846,(1.309to2.604, P=0.003);2.792(1.107to6.672, P=0.029) in dominant model, addictive model and recessive model when we adjusted the relevant risk factors.ConclusionRANTES-403G/A and-28C/G gene polymorphysm are risk factors to the risk of Takayasu arteritis BackgroundHeart failure (HF) is an urgent and emerging public problem. The incidence and mortality of HF requires global attention. Therefore, it is important to identify the protective factors and modify the risk factors to prevent disease progression. Evidence from animal, clinical and epidemiological studies have shown that the primary effective components in marine fish, n-3polyunsaturated fatty acids (n-3PUFA), have pleiotropic protective cardiovascular effects, including lowering blood pressure, modulating serum lipids, improving diabetes and insulin resistance, reducing arrhythmia, suppressing platelet aggregation, improving endothelial function, and inhibiting inflammation. All of these beneficial effects may reduce certain risk factors for HF, thereby contributing to its lower incidence.However, results from clinical trials have been variable. Several trials have observed that fish consumption is associated with reduced risk of HF, while others have reported the controversial results. Thus, it remained uncertain regarding the association between fish consumption and HF incidence.ObjectiveThe aim of our meta-analysis was to combine all published prospective cohort studies and determine whether fish consumption could lower the incidence of HF.MethodsWe performed a systematic search of Pubmed and Embase (from1953to June2012) using key words related to fish and HF. Studies with at least three categories of fish consumption reporting both relative risk (RR) and corresponding95%confidence interval (CI) for HF incidence were included. The pooled RR and95%CI were calculated using a fixed or random-effects model. Subgroup analysis was used to explore the potential source of heterogeneity. The generalized least squares regression model were used to quantify the dose-response relationship between fish consumption and HF incidence.Results Five prospective cohort studies including4750HF events of170231participants with an average9.7year follow-up were selected and identified. Compared with those who never ate fish, individuals with higher fish consumption had a lower HF incidence. The pooled RRs for HF incidence was0.99(95%CI0.91to1.08) for fish consumption1to3times per month,0.91(95%CI0.84to0.99) for once per week,0.87(95%CI0.81to0.95) for2to4times per week, and0.86(95%CI0.84to0.99) for5or more times per week. An increment of20g of daily fish intake was related to a6%lower risk of HF (RR0.94,95%CI0.90to0.97; P for trend=0.001). Gender, follow-up term and the assessment methods of food-frequency questionaire were not modifiable factors to the results.ConclusionsThis meta-analysis suggests that there is a dose-dependent inverse relationship between fish consumption and HF incidence. Fish intake once or more times a week could reduce HF incidence. BackgroundEgg is one of the most common, available, and inexpensive food in our daily life. Egg serves as the major source of dietary cholesterol, containing213mg cholesterol per egg. Evidence from animal and human metabolic studies have found that dietary cholesterol from egg could raise serum levels of low density lipoprotein cholesterol (LDL-C), a well-established independent risk factor for cardiometabolic diseases including cardiovascular diseases (CVD) and diabetes. Besides dietary cholesterol, egg also provides other essential nutrients including high-quality proteins, unsaturated fat, folate, and various vitamins, which are regarded as the protective factors for health status. Partly owing to the multifacet effect of egg intake, current international dietary guidelines are conflicted in recommending or limiting egg consumption for prevention of cardiometabolic diseases.The controversy among the dietary guidelines may be directly derived from inconsistent results of epidemiologic studies about the relationship of egg consumption and cardiometabolic diseases. Some observational studies have reported that frequent egg consumption was associated with high risk of CVD or diabetes, while others have found null disease-specific association. Given the mixed results among the studies, a systematic review and meta-analysis will help to clarify this issue.ObjectiveTo assess the dose-response relationship between egg consumption and the risk of CVD and diabetes.MethodsWe systematically searched MEDLINE database through December2012. Fixed-or random-effects model was used to pool the relative risks (RRs) and their95%confidence intervals (CIs). Subgroup analyses was performed to explore the potential sources of heterogeneity. Weighted linear regression model was used to estimate the dose-response relationship.Results Fourteen studies involving320778subjects were included. The pooled RRs of the risk of CVD, CVD for separated diabetes patients, and diabetes for the highest vs lowest egg intake were1.19(95%CI1.02to1.38),1.83(95%CI1.42to2.37),1.68(95%CI1.41to2.00), respectively. For each4/week increment in egg intake, the RRs of the risk for CVD, CVD for separated diabetes patients, diabetes was1.06(95%CI1.03to1.10),1.40(95%CI1.25to1.57),1.29(95%CI1.21to1.37), respectively. Subgroup analyses showed that population in other western countries have increased CVD than ones in USA (RR2.00,95%CI1.14to3.51vs1.13,95%CI0.98to1.30, P=0.02for subgroup difference).ConclusionsOur study suggests that there is a dose-response positive association between egg consumption and the risk of CVD and diabetes. |
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