Clinical Research On ZiYinQianYangHuaYu Decoction In Treating Senile Diabetes Mellitus Combined With Hypertension Yin Deficiency And Yang Hyperactivity And Stasis

Purpose:To discuss the understanding of traditional Chinese medicine about nodular goite, using Removing Phlegm and Activating Blood Circulation to Eliminating Goiter Decoction to interfere in the Syndrom of Turbid Phlegm and Blood Stasis.To observe the therapeutic efficacy of this decoction in treating the Syndrom of Turbid Phlegm and Blood Stasis.Methods:A randomized, controlled trial was conducted60patients with nodular goite were randomly classified into two groups.On the basic of modern medicine, the patients of treated group (n=30) were treated by Chinese medicine while the patients of controlled group (n=30) were not.Six months was a course of treatment.The observed indexes included both curative effect indexes, such as clinic symptoms, Thyroid morphology, serum the thyroid spectrum, thyroglobulin, IL-6, TNF-a, hemorheology,and safety indexes,such as routine urine,blood and stool test,ECG,the function of live and kidney and harmful reaction.The complete data carries on statistics analysis by the SPSS15.0statistics software.Results:Confirmed and incorporated in the elderly diabetic patients with Yin deficiency and Yang hyperactivity clip stasis in60cases of hypertension (treatment30cases in the control group of30cases), treated the first two courses in gender, age group, baseline data, such as statistical analysis no significant differences in comparability.①on the symptoms and signs of improvement:the treatment group patients symptoms improved markedly after treatment, total effective rate93.33%;66.67%total effective rate of the control group. Symptoms treatment groups improved conditions better than the control group (P<0.01).②hypoglycemic effects: the treatment group and the control group patients with blood glucose, blood pressure, glycosylated hemoglobin are significantly reduced, compared with before treatment showed a significant difference (P<0.01); the treatment group after treatment fasting glucose to upgrade the standard of significant differences in the control group (P<0.01), postprandial blood glucose, glycosylated hemoglobin, blood pressure treatment group improved compared with the control group difference (P<0.05).③the lipid effects:treatment in patients with TC, TG, reduced LDL-C compared with before treatment (P<0.01), HDL-C rise compared with before treatment (P<0.01); the control group patients with TC levels (P<0.01), elevated HDL-C levels (P<0.01), but the TG, LDL-C are not significantly different compared with before treatment. Group TC, HDL-C improve the situation between the two groups are not significantly different.④blood rheological learn:treatment group treatment Hou full blood stick degrees (Gauche, and in the cut, and low cut), and plasma stick degrees more treatment Qian are declined (P<0.05), against group full blood stick degrees (in the cut) and plasma stick degrees more treatment qian are declined (P<0.05), but plasma stick degrees (Gauche, and low cut) treatment before and after no differences. group between comparison treatment group full blood stick degrees (in the cut) of declined range more against group has significantly differences (P<0.01), but plasma stick degrees of declined level two group no obviously differences (P>0.05). Two sets of hematocrit without obvious changes before and after treatment.⑤fasting insulin and two sets of HOMA2-IR and HOMA2-%B before and after treatment index:fasting insulin and HOMA2-IR are two groups of patients after treatment has been reduced, two groups of patients after treatment HOMA2-%B expected to rise, compared with before treatment had significant differences (P<0.01); improvement in fasting insulin, HOMA2-IR, and HOMA2-%B treatment groups compared with the control group there were significant differences (P<0.01).⑥Security indices:liver and kidney function tests are in the normal range. Both groups had no adverse reaction.Conclusion:Judging from preliminary clinical study, of nourishing yin and Yang and blood stasis treated by Western medicine combined with Western medicine treatment more effective than simple. Instructor experience treatment can improve the clinical symptoms of elderly patients with diabetes mellitus combined with hypertension, lower blood sugar, blood pressure, blood lipid, can improve blood rheology in pancreatic islet beta cell function, insulin resistance index and indices, and safe, effective, and has a broad prospect, deserve further in-depth study.