A Literature Mining And Randomized Controlled Trial Of Moxibustion In Treating Primary Dysmenrrhea

ObjectiveMethods of literature research, Clinical investigation, expert consultation and demonstration were applied in my dissertation to find all the studies about moxibustion treatment for primary dysmenorrhea. Meanwhile, standardized clinical study, evidenced data and easily promoted treatments, were all designed scientifically in my dissertation, which provide the highly qualified evidence to the clinical application of moxibustion treatment for primary dysmenorrhea with non-drug therapy of traditional Chinese medicine.Methods1. Data mining technology comprehensive system were applied to collect the ancient and modern, Chinese and foreign Monographs and journal literature in treating primary dysmenorrheal by moxibustion. The last treating prescription were set up according to clinical research, expert advice, demonstration and other methods in choosing moxibustion acupuncture point.2. This study is a randomized controlled trial (RCT).152cases were randomly divided into group A (moxibustion group) and group B (fenbid group) treated patients.19cases were lost or dispelled from the study during the treatment. There were69patients in Group A administrated moxibustion treatment. And64patients in group B administrated fenbid. The treatment cycle was3months. Curative effect evaluation standard were as follows:(1) within the group and between groups of VAS scores before and after treatment scores change;(2) into the group of0days RSS retrospective rating scale with three menstrual symptoms after treatment of COX, the dysmenorrhea symptom rating scale change related standards of evaluation.(3) the numerical variation before and after examination on PGF2,and OT in both groups were observed.Results 1. Literature Review:(1)Ancient Literature Review:the first three mainly used acupoints treatment are GuanYuan, ZhongJi, SanYinJiao. Ren Meridian and Foot shaoyin meridian are the acupoints chosen frequency meridians.(2)Contemporary literature review:the first most commonly used way is moxa cone moxibustion then is the moxa stick moxibustion. The first three commonly used acupoints are GuanYuan, ShenQue, SanYinJiao. Acupoints chosen frequency meridians are Ren Meridian and foot Taiyang meridian. The main acupoints chosen in contemporary literature are GuanYuan, ShenQue, and ZhongJi. The main acupoint are mostly on Ren meridian. Moxibustion is applied to the sufficiency syndrome. The study mostly focuses on the cold and dampness sluggish type and Qi stagnation and blood stasis type in the sufficient syndrome. The moxibustion treatment steps in7days before the menstruation according to the literature review. Moxibustion treatment lasts until the arrival of the menstruation. The course of treatment last for7days. The treatment cycle was3months.2.Clinic Study Results:①Set of VAS scores before and after treatment results:the VAS scores analysis in two groups before and after treatment shows statistical significance (P<0.01).②The COX dysmenorrhea symptom score comparison before and after treatment in two groups:A:Dysmenorrhea symptom onset cumulative time results:P values is less than0.01in group A during all assessments; the ratio in first and the second treatment is less than0.05in group B.Later, it is less than0.01.B:Symptom severity situation results:after three courses of treatment in moxibustion group, comparing with the baseline, syndromes of nausea, vomiting, loss of appetite, back pain, leg pain, fatigue, dizziness, diarrhea, insomnia, irritability, complexion change are all released(P<0.01); Headaches, depression, neuroticism reduces (P<0.05). After three courses of treatment, comparing with the baseline period in Western medicine group, syndromes of loss of appetite, skeletons, back pain, fatigue, diarrhea, complexion change, insomnia and whole body pain are released (P<0.01); Nausea, vomiting, headache, leg pain, stomach pain and irritability is lessening (P<0.05).③Two groups of VAS score comparison results:scores of the two groups at baseline and after the third treatment comparison shows that P is more than0.05. Comparison between the first and second treatment, in Western medicine group, it shows that P<0.01.④The COX dysmenorrhea symptom score comparison between two groups:from attacking time and severity, the moxibustion group is better than western medical group in loss of appetite and neurotic (P<0.01). So is in reducing the onset and severity of diarrhea and depression (P<0.05).⑤For the two groups of subjects, PGF2a and OT before and after treatment have a statistically significant difference with P<0.01within the group, while there were no significant differences between groups.⑥Comparison of VAS and cox index after follow-up and three menstrual cycles in the moxibustion group shows P>0.05, while the VAS and COX of abdominal pain in the western medicine group shows statistically significant,which means that the effects rebound. The VAS comparison between two groups has no significant difference. The moxibustion group is better than western medical group in loss of appetite and neurotic (P<0.01). So is in diarrhea, depression, and irritability (P<0.05).Conclusion1. The literature results show that the first three commonly used acupoints to treat primary dysmenorrhea are GuanYuan, ShenQue, SanYinJiao.The cold-damp stagnated type and gas and blood blocking type are the most often used for moxibustion treatment. The moxibustion treatment steps in7days before the menstruation is assertained.2.Between the two group shows are statistically significant. Dysmenorrhea accompanied symptoms in two groups differently improved after every treatment. The scores of PGF2。and OT after treatment were effectively lower than those before treatment within the group.3.After the first and second treatment, comparing with the western medicine, moxibustion group has a slowly long analgesia effect, which play an obvious advantage. After three continuous treatment during three menstrual cycles, the analgesic action of moxibustion can achieve the same analgesic affect as the western medicine group.And moxibustion is better than western medicine group in reducing loss of appetite, neurotic, diarrhea, and the onset of depression. What comes to the comparison among the two groups in the reduction of PGF2。and OT, there are no significant difference.4.Follow-up period:the sustaining curative effect of moxibustion group in the first menstrual cycle is slightly better than western medicine group, which shows that moxibustion has a sustaineing and stable curative effects than western medicine group.