Clinical Research On Chronic Atrophic Gastritis Due To Spleen Deficiency Damp Heat Syndrome Treated By Ershensancao Decoction

Objective:The chronic atrophic gastritis, a sort of chronic gastritis, is a common, frequent disease in an internal digestive medicine department. If it comes with medium or high level of intestinal metaplasia or dysplasia, it shows a strong tendency to turn into gastric cancer. So regarding the cure for this disease, gastric carcinoma prevention has already become an important point of the research activities in the Division of Digestive Disease, both in Western and traditional Chinese medicine. Western medicine has not found a correct cause of CAG, and there is no officially recognized treatment for it. Professor Shan has more than50years of experiences in Chinese medicine. He has achieved a remarkable outcome in spleen and stomach disease theory, research, and clinical practice. To treat and diagnose chronic atrophic gastritis, he combined Chinese medicine with modern medicine, and created a leading-edge experiential herbal decoction-ErshenSancao decoction.Method:From the patients coming to Professor Shan’s office from2009to2012who were diagnosed with chronic atrophic gastritis, we selected104examples which match up with the Chinese diagnosis standard of spleen deficiency damp heat syndrome. We prescribed them Professor Shan’s ErshenSancaotang (Taizishen, Huangqi, Chaobaizhu, Danshen, Yiyiren, Xianhecao, Sheshecao, Gancao), then adjusted medication dose (boiling in water, twice a day) according to their symptoms for six months.Result:Observing the results before and after treatment for104examples (male54, female50), we found the effective ratio in gastro scope is75.9%, and atrophy, intestinal metaplasia and dysplasia all showed significant difference (P<0.05).53Helicobacter pylori-infected patients, also show statistical difference (P<0.05). According to the result, the effective ratio of clinical symptoms showed remarkable difference (t=17.84, P<0.01). This explains that Proressor Shan’s ErshenSancaotang is very effective to the patients of chronic atrophic gastritis spleen deficiency damp heat syndrome.Conclusion:According to the6month’s research, ErshenSancaotang can ease the clinical symptoms such as stomachache, gas, bloating exta, and also can improve gastro scope signs. And there was no serious untoward effect was reported, which means that this treatment is safe for at least6months. This thesis analyzes and provides clinical evidences for Professor Shan’s ErshenSancaotang treatment. We hope that it can help reduce pain in CAG patients all over the world.