A Study Of Three-dimensional Mesh Titanium Mandibular Prosthesis Fabricate Using 3D Printing Technology

[Backgroud]Mandibular continuity defects result from a variety of causes,including maxillofacial trauma,osteomyelitis,osteonecrosis,and resection of benign or malignant tumors.Despite several techniques have been described for the reconstruction of mandibular defects along the past decades,segmental mandibular bone repair remains a challenge.The mandibular continuity was provided by alloplastic biocompatible plates and customized prosthesises that are properly shaped,outcomes of alloplastic reconstructions were often not possible to reproduce both the complex facial contours and functional recovery with stock plates and prosthesises.In light of this,tissue engineering might offer a next step in the evolution technology,the mesh structure with freedom design can be manufactured.Therefore,by using 3D printing technologies,more consideration on bionic structural and mechnical parameter is a singnificant research for mesh structure design and manufacturing of titanium mandibular prosthesis.In order to take full advantage of customized implant directly manufactured by 3D printing,researching on customized implant design and manufacturing is very meaningful.[Objective]To investigate a ideal modelling method of designing 3D mesh scaffold substitutes based on tissue engineering to restore mandibular bone defects.By analyzing the theoretical model from titanium scaffolds fabricated by 3D printing,the feasibility and effectiveness of the proposed methodology are properly verified.[Method]Part I In personalized design,the anatomical features of the human mandible and biomechanical features are analyzed.The customized design direction and mechnical requirements of the mandibular prosthesis are summarized and the modeling method is proposed.Part ? The usage of 3D printing processes enables the creation of titanium mandibular prosthesis with arbitrary 3D mesh structure satisfying both the mechanical and the biological requirements for mandibular reconstruction.To obtain the regeneration scaffold with prosthesis shape and microstructure for mandibular defects with TE.Furthermore Unigraphics software NX 8.0 was applied on Boolean calculation of subtraction between prosthesis and regular microstructure structure and ANSYS 14.0 software were applied to design the inner construction of 3D mesh scaffolds,adjust topological structure and the geometrical parameters of 3D mesh titanium scaffolds according to the and establishes optimized structure and maximal strength with minimal weight.Part ? The 3D mesh prosthesis solid model through computer-aided technology methods imput into Electron Beam Melting(EBM)equipment to fabricate Ti-6A1-4V scaffolds.Part ? The microstructural and mechanical properties of Ti6A14V samples produced by Electron Beam Melting(EBM)/Selective Laser Melting(SLM)are studied.[Results]The 3D mesh scaffold designs were numerically investigated by using an optimization approach-FEA,stress peak value decline 10%,volume decrease 43%,porosity increase to 76.32%,which beam elements were used to create the 3D mesh structures of the scaffolds.The EBM-printed three-dimensional mesh titanium scaffold with struts diammer 0.5mm,porosity 88.5%,ultimate compressive strength 131N can meet the requirements of mandibular reconstruction.[Conclusion]3D printing technology has made it possible to design and render patient-specific shapes with mesh structures that can appropriately translate strain through reconstructed anatomy.It demonstrated the possibility of providing topological optimized 3D mesh architectures scaffolds for mandibular bone regeneration by considering both mechanical and biological aspects,using 3D printing technology and FEA.