The Indicator Effect Of Erythrocyte Intracellular Free Magnesium In Brain And Periphery

Magnesium(Mg²⁺)participates in many crucial physiological activities.The stable of body Mg²⁺ directly correlates with life quality.Unbalance of body Mg²⁺ level was found in many diseases,while regulation of body Mg²⁺ status could rescue some of the diseases successfully.The detection of body Mg²⁺level is very important for disease diagnosis and drug treatment.However,there isn’t a very effect Mg²⁺ marker by now.Previous literatures reported that there are various problems of traditional magnesium indexes.In this paper,we evaluated a variety of magnesium components in the blood,cerebrospinal fluid and tissues of mice and rats.The metabolic curves of these magnesium indexes were detected by acute magnesium administration.According to their metabolic rate,the theoretical model of these indexes is summarized.We evaluated this model in chronic abnormal Mg intake,aging and metabolic syndrome.It was found that erythrocyte intracellular free magnesium(RBC [Mg²⁺]_i)could present all these chronic physiological and pathological processes,while erythrocyte total Mg and plasma Mg²⁺was not responsive to the processes.In addition,in the process of metabolic syndrome,the RBC [Mg²⁺]_i could display the metabolic abnormalities earlier than the fasting blood glucose and serum insulin.Besides,the author also studied the significance of RBC [Mg²⁺]_i in the central nervous system.It was found that RBC [Mg²⁺]_i was linear correlated to recognition memory and spatial working memory.Under Mg compound treatment,the animal memory level produced a consistent pattern of change with the RBC [Mg²⁺]_i.As a summary,we propose that the RBC [Mg²⁺]_i is the most representational body magnesium marker in the chronic physiological and pathological processes.It may have potential value in the optimization of diet structure,the early diagnosis and monitoring of related diseases,as well as the accuracy medicine of the individual with magnesium compound.