Au Nanorods Based Composite Materials For Cancer Therapy

To date,cancer has become the most important public health problem in the world,and the morbidity and mortality of cancer have been increasing year by year in China.Among the current cancer therapies,photothermal therapy shows the potential to replace the traditional therapies because of its high specificity,small trauma and selectivity.The selection of photothermal conversion agents is crucial in photothermal therapy,and Au nanorods(AuNRs)have attracted much interest.Although AuNRs show good biocompatibility,strong absorption in near infrared and passive targeting in tumor tissue,but the utilized CTAB in the synthesis process possessed high cytotoxic,limiting the further application of AuNRs.Therefore,further modification of CTAB stabilized AuNRs to reduce the toxicity has become the focus of the AuNRs studies for photothermal therapy.In this thesis,materials with good biocompatibility have been utilized to modify CTAB stabilized AuNRs,and four kinds of photothermal therapeutic materials with excellent properties have been prepared.The main contents are as follows:(1)Zeolite imidazole framework-8(ZIF-8)coated AuNRs(AuNRs@ZIF-8)ZIF-8 was coated on AuNRs as a hyperthermia agent for enhanced photothermal therapy.The coating of AuNRs with ZIF-8 not only decreases the cytotoxicity of CTAB-stabilized AuNRs,but also enhances the photothermal efficiency of AuNRs.More importantly,the in vitro PTT studies showed that ZIF-8 coated AuNRs were effective for photothermal destruction of cancer cells.(2)Polydopamine(PDA)coated AuNRs(AuNRs@PDA)AuNRs was coated by PDA with different shell thicknesses and utilized as a hyperthermia agent for enhanced plasmonic photothermal therapy.The PDA coating of AuNRs not only decreases the cytotoxicity of CTAB,but also enhances the photothermal efficiency for reducing the required AuNRs concentration and laser power density.More importantly,the in vitro PTT studies showed that PDA coated AuNRs were effective for photothermal destruction of cancer cells.(3)Cyanine dye(Cy)mediated AuNRs assembly(AuNRs/Cy)Cy mediated assemblies of AuNRs were utilized as hyperthermia agents for imaging and enhanced photothermal therapy.The assemblies of AuNRs mediated by Cy not only enhance the photothermal efficiency for reducing the required concentration of AuNRs and laser power density,but also provide imaging function for the nanomaterials.Moreover,the in vitro PTT and imaging studies showed that assembled AuNRs and cyanine were effective for multifunction imaging and therapy of cancer cells.(4)Mesoporous silica(mSiO2)partly coated AuNRs(Janus AuNRs@mSiO2)Mesoporous silica was partly coated on AuNRs as a hyperthermia and drug delivery platform for chemo-photothermal therapy.The partly coating of AuNRs with mesoporous silica not only decreases the cytotoxicity of CTAB-stabilized AuNRs,but also combines the chemotherapy with the photothermal of AuNRs.More importantly,the in vitro chemo-photothermal therapy studies validated that Janus AuNRs@mSiO2 were effective for chemo-photothermal destruction of cancer cells.Photothermal materials with great stability,biocompatibility,and photothermal efficiency were prepared,and we expect the AuNRs-based photothermal materials investigated in the thesis would provide experimental basis for the chinical researches of photothermal therapy,and provide new ideas for the design of photothermal materials.