Study On The Association Between Serum Soluble Corin And Stroke

Part I association between the levels of serum soluble Corin and strokeObjective: Through evaluating the levels of serum soluble Corin of patients with acute stroke,we aimed to explore the association between Corin and acute stroke.Methods: 597 neurology clinic patients who were diagnosed acute stroke in the Second Affiliated Hospital of Soochow University,the affiliated Hospital of Xuzhou Medical College and Changda hospital in Ashan from January 2014 to May 2014 were enrolled in the study.Collecting the patients general clinical information:(1)demographic data,possible risk life-style,clinical history and family history of cardiovascular or cerebrovascular diseases and so on;(2)blood pressure、height、weight、waist circumference;(3)Blood samples were collected to detect blood lipids,blood glucose、uric acid and other biochemical parameters,the serum and plasma were separated,and the blood samples were stored at-80℃;(4)Detection of serum Corin concentration.2498 healthy people without coronary heart disease were recruited as a control group from January to May 2010 in Suzhou.Previous studies have indicated that there was a difference in the level of serum Corin in gender,therefore,we compared the single male group and female group,respectively.Results: Ischemic and hemorrhagic stroke patients had a significantly lower level of serum soluble Corin than healthy controls in men and women(all P <0.05).In multivariate analysis,men in the lowest quartile of serum soluble Corin were more likely to have ischemic(OR,95%CI: 4.90,2.99-8.03)and hemorrhagic(OR,95%CI: 17.57,4.85-63.71)stroke than men in the highest quartile.Women in the lowest quartile of serum soluble Corin were also more likely to have ischemic(OR,95%CI: 3.10,1.76-5.44)and hemorrhagic(OR,95%CI: 8.54,2.35-31.02)stroke than women in the highest quartile.ORs of ischemic and hemorrhagic stroke were significantly increased with decreasing levels of serum soluble Corin in men and women(all P for trend <0.001).Conclusion: Compared with the healthy controls,serum soluble Corin levels in patients with acute stroke were decreased.It suggested that decreased circulating soluble Corin might be a risk factor or a marker for stroke.Part Ⅱ Relationship between Corin and the prognosis of strokeObjective: It has been demonstrated that the levels of serum soluble Corin were associated with acute stroke in part one.However,whether it is associated with stroke prognosis or not,it still has not been studied.Therefore,we continued to study the correlation among the levels of serum soluble Corin and prognosis of acute stroke.Methods: 522 stroke patients were followed at the point of 3 months after stroke.The follow-up works were completed by unified training full-time neurological physicians,such as questionnaire,clinical survey,life dependence and measurement and evaluation of neurological function.In the study,Stroke prognosis depended on major disability,death and vascular events.Results: Patients with high Corin had a significantly lower crude risk for the composite outcome of major disability,death,or vascular events(OR=0.67,95%CI: 0.45-0.99)and the composite outcome of major disability or death(OR=0.64,95%CI: 0.43-0.96)than patients with low Corin.After adjustment for age and baseline NIHSS score,patients with high Corin still had a significantly lower risk for the composite outcome of major disability or death(OR=0.60,95%CI: 0.36-0.99).After further control of other confounding factors,such as age,sex,baseline NIHSS score,hours from onset to hospitalization,smoking,drinking,hypertension,diabetes,coronary heart disease,atrial fibrillation,family history of stroke,and stroke subtype,odds of the composite outcome of major disability,death,or vascular events(OR=0.64,P = 0.069)and the composite outcome of major disability or death(OR=0.61,P = 0.058)were still lower in high Corin group than low Corin group,although the P values were not significant but close to significance.Conclusion: High serum soluble Corin predicted lower risk for poor outcomes including major disability,death,or vascular events within 3 months after stroke.Our results indicated a favorable effect on stroke prognosis.However,the predicting effect of serum soluble Corin on stroke prognosis warranted further study with larger sample size.