| Purpose:Parkinson’s disease is a neurodegenerative disease which increases with age.The ageing of population in our country has caused the increase in the number of patients with PD.Parkinson’s disease has a high disability rate,prominent motor symptoms,and lots of non-motor symptoms,leading to progressively limited mobility,affecting one’s ability to self-care and ability to work.In addition,Parkinson’s disease is a refractory disease with a long course of treatment.Patients have to increase dosage gradually while the effect of medication will gradually decrease.There will be toxic side effects and complications of Western medicine.Therefore,the treatment of PD is very tricky and needs to be resolved.In recent years,there are more and more research reports on the treatment of PD with acupuncture therapy,reflecting the safety,effectiveness and scientificity of acupuncture therapy for PD.Du meridian activating acupuncture therapy is a commonly used and effective therapy for clinical treatment of PD by Professor Zhuang Lixing.Three-needle trembling therapy is an effective therapy found by Professor Jin Rui and after lots of efficacy verification.Based on the clinical experiences of Professor Zhuang Lixing’s Du meridian activating acupuncture therapy and Professor Jin Rui’s Three-needle trembling therapy for PD,this study aims to observe the clinical effect of the Du meridian activating acupuncture therapy combined with Three-needle trembling therapy in the treatment of PD.It was compared with Du meridian activating acupuncture therapy andThree-needle trembling therapy respectively.The purpose of this study was to further verify the effectiveness of Du meridian activating acupuncture therapy and Three-needle trembling therapy for the treatment of PD.In addition,it was to explore the theoretical basis and mechanism of the combination of Du meridian activating acupuncture therapy and Three-needle trembling therapy in the treatment of PD,so as to provide clinically safe,feasible and more effective therapeutic methods.Method:In this study,90 patients were randomly divided into the treatment group,the control group one and the control group two.In addition to maintaining Western medicine treatment,three acupuncture therapies with different main acupoints were separately added.The treatment group selected Baihui,Shenting,Yintang,Suliao,Houxi,Shenmai,Sishenzhen,Fengchi,Hegu and Taichong,used mild reinforcing-reducing method.The control group one selected Baihui,Shenting,Yintang,Suliao,Houxi and Shenmai,used mild reinforcing-reducing method.The control group two selected Sishenzhen,Fengchi,Hegu and Taichong,used mild reinforcing-reducing method.According to different diagnosis of TCM syndromes,acupoints are allocated.The syndrome of stirring wind due to phlegm-heat selected Yinlingquan and Fenglong,used lifting-thrusting draining method.The syndrome of stirring wind due to blood stasis selected Yinlingquan and Xuehai,used lifting-thrusting draining method.The syndrome of deficiency of liver and kidney selected Xuanzhong and Sanyinjiao,used lifting-thrusting supplementation method.The syndrome of deficiency of both qi and blood selected Qihai and Xuehai,used lifting-thrusting supplementation method.The syndrome of deficiency of both Yin and Yang selected Sanyinjiao and Guanyuan,used lifting-thrusting supplementation method.After the arrival of Qi,manipulated the needles for every 10 minutes and removed the needles after 30 minutes.The patients were treated for 5 days and rested for2 days for a total of 6 weeks.The patients were assessed with seven curative effect indicators,including the Unified Parkinson’s Disease Rating Scale(UPDRS),Parkinson’s Disease Non-Motor Symptoms Scale(NMSS),the Scales for Outcomes in Parkinson’s disease–Autonomic(SCOPA-AUT),Parkinson’s Disease Sleep Scale(PDSS),Hamilton Depression Rating Scale(HAMD-24),FatigueScale-14(FS-14),and the Quality of Life questionnaire for Parkinson’s Disease of Traditional Chinese Medicine(TCM QOL).After the data was collected,SPSS 21.0 statistical software was used for statistical analysis.Result:1.Basic situation: All 90 cases admitted in this study had neither adverse reactions nor alopecia.The grouping result was 30 cases in each group.There was no statistically significant difference among these three groups in terms of gender composition,age,duration of disease,severity of symptoms,TCM syndrome types,and the respective scores of the seven curative effect indicators before treatment(P > 0.05),indicating that three groups of patients were comparable.2.UPDRS: The differences of total score and sub-item score among these three groups before and after treatment were statistically significant(P<0.05).After treatment,there were statistically significant differences between the treatment group and two control groups in terms of mental-emotional behavior and self-care ability(P<0.05),while no statistically significant difference between control group one and control group two(P>0.05).It was indicated that all groups can reduce the total score and sub-item score of UPDRS.In terms of the improvement of score of mental and emotional behavior and self-care ability,the treatment group was superior to control group one and control group two.There was no statistically significant difference in efficacy among these three groups(P>0.05),indicating that the efficacy of these three acupuncture therapies were basically the same.3.NMSS: The differences among these three groups before and after treatment were statistically significant(P<0.05).After treatment,there were statistically significant differences of total score among the three groups(P<0.05).In terms of attention and memory,gastrointestinal symptoms and urinary symptoms,there were statistically significant differences between the treatment group and two control groups,(P<0.05),while no statistically significant difference between the treatment group and control group one(P>0.05).It was indicated that these three groups can reduce the total score and sub-item score of NMSS.In terms of the improvement of total score of non-motor symptoms,the treatment group was superior to control groupone,besides the control group one was better than control group two.In terms of the improvement of attention and memory,gastrointestinal symptoms and urinary symptoms,the treatment group and control group one were superior to control group two.There was no statistically significant difference in efficacy among these three groups(P>0.05),indicating that the efficacy of these three acupuncture therapies were basically the same.4.SCOPA-AUT: The differences among these three groups before and after treatment were statistically significant(P < 0.05).In terms of pupil adjustment function,there was no statistically significant difference among these three groups before and after treatment(P>0.05).It was indicated that these three groups can reduce the total score of SCOPA-AUT and the sub-item score except for the pupil adjustment function.There was no statistically significant difference in efficacy among these three groups(P > 0.05),indicating that the efficacy of the these three acupuncture therapies were basically the same.5.PDSS: The differences among these three groups before and after treatment were statistically significant(P<0.05),indicating that these three groups can increase the total score of PDSS.There were statistically significant differences in efficacy among these three groups(P<0.05),indicating that in the improvement of sleep,the efficacy of the treatment group was superior to control group two,and the efficacy of control group two was better than control group one.6.HAMD-24: The differences among these three groups before and after treatment were statistically significant(P<0.05),indicating that these three groups can reduce the total score of HAMD-24.There were statistically significant differences in efficacy among these three groups(P<0.05),indicating that in the improvement of depression,the efficacy of the treatment group was superior to control group two,and the efficacy of control group two was better than control group one.7.FS-14: The differences among these three groups before and after treatment were statistically significant(P<0.05).After treatment,there were statistically significant differences of total score between the treatment group and two control groups(P<0.05),while no statisticallysignificant difference between control group one and control group two(P>0.05).It was indicated that these three groups can reduce the total score of FS-14.In terms of the improvement of fatigue,the treatment group was superior to control group one and control group two.There were statistically significant differences in efficacy among these three groups(P<0.05),indicating that in the improvement of fatigue,the efficacy of the treatment group was superior to control group one,and the efficacy of the control group one was better than control group two.8.TCM QOL: The differences among these three groups before and after treatment were statistically significant(P<0.05).After treatment,in terms of total score,physiological function and psychological state,there were statistically significant differences between the treatment group and two control groups(P < 0.05),while no statistically significant difference between control group one and control group two(P>0.05).In terms of social relationship,there was no statistically significant difference between before and after treatment among three groups.It was indicated that these three groups can reduce the total score of the TCM QOL and the sub-item score except for the social relationship.In terms of the improvement of total score,physiological function and psychological state,the treatment group was superior to control group one and control group two.There was no statistically significant difference in efficacy among these three groups(P > 0.05),indicating that the efficacy of these three acupuncture therapies were basically the same.Conclusion:1.These three therapies including Du meridian activating acupuncture therapy combined with Three-needle trembling therapy,Du meridian activating acupuncture therapy and Three-needle trembling therapy are safe and effective.2.These three therapies including Du meridian activating acupuncture therapy combined with Three-needle trembling therapy,Du meridian activating acupuncture therapy and Three-needle trembling therapy can regulate motor function and autonomic nervous function,reduce non-motor symptoms and complications,improve sleep,depression and fatigue,and improve the quality of life of patients with Parkinson’s disease.3.Compared to only using Du meridian activating acupuncture therapy or only using Three-needle trembling therapy,the combination of Du meridian activating acupuncture therapy and Three-needle trembling therapy can enhance the therapeutic effect of non-motor symptoms including gastrointestinal symptoms,urinary symptoms,mental disorders,sleep disorders and fatigue.It can improve the clinical efficacy of Parkinson’s disease and is worth promoting. |
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