Pathological Mechanism Analysis And Clinical Application Study Of Atherosclerosis Based On Hemodynamics

Vascular disease is the leading cause of death.It is also humanity's greatest medical and health challenge at this stage.It is less likely to understand the specificity of the lesion location only from the perspective of medical and clinical research.The mechanism of arterial disease can only be fully elucidated by combining the characteristics of blood flow.At the same time,the study of arterial diseases from the perspective of treatment can no longer meet the requirements of human health in modern times.Therefor,it is necessary to study the arterial diseases and its evolution mechanism from a multidimensional perspective.Thus active preventive measures and accurate treatment plan may become true.A fluid-solid interaction mechanical research method is applied to study the mechanism of arterial disease based on the medical imaging of human arteries.Mechanical model of arterial blood fluid characteristic model is established via fluid dynamics analysis and dynamic simulation.The fluid characteristics of arterial blood flow is analysed under the influence of vascular structure and pathological process to study the arterial lesions and progression.The main research contents and research results are as follows:1.mathematical description of blood flow is built.The mechanical characteristics in local vessel unit and fluid characteristic of blood flow is analysed.The impact of fluid dynamic factors towards arterial lesion mechanism is studied.Flow separation area is taken into consideration to reveal the fluid characteristics at the lesion site.Mathematical model of arterial blood flow is established based on vascular structural and blood fluid characteristics.The influencing mechanism of blood fluid characteristics changing on leision site is studied.According to research,obvious flow separation occurs in the narrow area and the bifurcate area of aterial vessel with low speed and low shear stress.The fluid environment is suitable for lesion to take place.2.A modeling approach is established suitable for fluid solid interaction calculation on blood flow numerical simulation based on medical imaging technology.Quantitative analysis model based on the effect of vessel structure and blood parameter on blood fluid characteristics is applied to study the hemodynamic factors in vascular pathological process as evaluation and assessment.Three-dimensional geometric model based on medical imaging is applied in the fluid-solid interaction simulation in order to take the elasticity of vessel wall into consideration in the description of fluid characteristics.Arbitrary lagrangian-eulerian method is discretely analyzed.The computational simulation of blood flow based on the geometric model obtained from medical image proved the mathematical analysis conclusion.3.The fluid-solid interaction numerical simulation is applied to study the impact of basic structure of arterial vessel on blood flow.The fluid characteristics are analized and compared under different circumstances in narrow area and bifurcate area.The impact on arterial lesion is researched in order to propose new hemodynamic index in clinical test.According to research,secondary flow generated by the narrow structure and bifurcate structure maintains with low speed and low shear stress.It causes pathological factors to stick and subside on endovascular tissue.The comparison of arterial vessels from different degree of lesion shows that the lesion progress accerates after atherosis,and the focal character of atherosclerosis is more obvious.4.Geometry reconstruction is carried out for the levorotatory branch of the coronary artery based on medical image.Bidirectional fluid-solid coupling method is approached to simulate the blood flow within one cardiac cycle.The fluid characteristic is analyzed to prodict the location of atherosis and the pathological trend.Mechanical research method is used to assist the medical terminal detection.The numerical simulation is approached which is proved efficient in Local arterial structure.A new method is established for studying the hemodynamic factors of pathological mechanism in real vascular system.The research findings lay the foundation of the practice of numerical simulation in clinical test.5.The blood flow characteristics analyse is compared with the clinical test methods at this stage.The clinical application of hemodynamic analyse based on fluid-solid interaction is studied.The value of clinical application is revealed.The way of clinical use of the research achievement of this study is pointed out.