| The role of charge density in polyelectrolyte multilayer coatings used in 2-D cell culture was investigated in this dissertation. First it is important to comprehend that cells do not attach directly to surfaces, they attach to proteins adhered to surfaces. Surface charge density in polyelectrolyte films affects not only protein coverage, but also interferes with protein exchange (Vroman effect), highly charge surfaces favor irreversible absorption of non-adhesive proteins like albumin, which directly affects cell behavior on these ultrathin films. |
