X-ray crystallographic studies on the structural conversion from B-DNA to A-DNA and the sequence effect on the helix-handedness

The structural conversion between B-DNA and A-DNA has been conducted by the introduction of the ribose residues in the B-DNA decamer d(CCGGCGCCGG). The two chimeric duplexes d(CCGGC)r(G)d(CCGG) and r(C)d(CGGCGCCG)r(G) exhibit typical A-DNA geometry, with all the sugars in the C3;The helix-handedness of an oligonucleotide is highly influenced by its sequence. It has been known that the alternating oligonucleotides starting with a 5...