Transcriptional regulation of the human apolipoprotein AII gene by the sterol regulatory element binding protein 1 (SREBP-1)

The mechanisms of transcriptional regulation of the human apolipoprotein A-II gene by SREBP-1 have been investigated. Binding of SREBP-1 to the apoA-II promoter was initially detected by screening a human liver cDNA library using the element AIIAB as a probe. DNaseI footprinting with SREBP-1 (1-460) identified five binding elements: AIIAB (...