Neuropeptide Y structure and function: Constrained peptidomimetics and non-peptide mimics as receptor probes

Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter, recognized as a member of the pancreatic polypeptide family and ubiquitously distributed in the mammalian central and peripheral autonomic nervous systems. Peripherally, NPY functions as a vasoconstrictor, while centrally it is involved in the modulation of anxiety, mood, eating behavior, and other CNS pathology. NPY is known to bind at least five different receptor subtypes (...