| Immune system responses to foreign entities are preceded by specific interactions between T lymphocytes and antigen presenting cells. The form of antigen recognized by the antigen specific T-cell receptor (TCR) on T lymphocytes is a complex between immunogenic peptide fragments and host peptide binding proteins called major histocompatibility complex (MHC) molecules. Formation of a functional peptide/MHC complex and its binding by the appropriate TCR underlies the specificity of immune responses.;To investigate peptide/MHC association, I expressed a murine class II major histocompatibility complex heterodimer, E;Site-directed mutants of E... |
