Characterization and isolation of a beta-cell surface receptor for diabetogenic EMC-D virus and studies on the relationship between receptor number and pathogenesis in virus -induced IDDM in mice

he diabetogenic variant of EMC virus, EMC-D, can infect mouse pancreatic ;The nature of the EMC-D virus receptor was investigated by in vitro attachment of ;The Hill analysis result is supported by the detection of two affinity purified putative receptor proteins (M.W. 97,000 & 70,000 daltons) from BMP cells. Chromatofocusing studies on these proteins confirmed that the putative virus receptor contains Neu5Ac. Monoclonal antibodies raised against the putative receptor blocked EMC-D virus infection of BMP cells and virus binding to...