| Deleted in colorectal cancer (DCC) is a type I transmembrane glycoprotein with a single membrane-spanning domain. It is expressed in commissural axons and growth cones where it functions as a cell-surface receptor for netrin-1. The crystal structures of DCC FNIII-5 domain and VI-V domain of netrin-1 are described. The binding of netrin-1 to various DCC domains is characterized.;The role of Semaphorin 3A in lipoxygenase-dependent signalling in the recovering brain following an experimental stroke is addressed. Sema3A acts through 12hydroxyeicosatetraenoic acid, and 12-hydroperoxyeicosatetraenoic acid, the metabolites of 12/15- lipoxygenase, resulting in anti-axon growth and antiangiogenic effects. Signalling through the Sema3A pathway after an experimental stroke can lead to further damage at the site of injury, and blocking the 12/15-LOX activity can prevent this damage. |
