| Current and future trends in the delivery of Active Pharmaceutical Ingredients (API) have led to an explosion into the research of the development and understanding of novel drug delivery systems with the capacity to delivery drugs with increasing accuracy and efficiency. The advent of the discoveries made in the human genome project enables genetic and anthropometric information about individuals to be utilized to deliver tailored strategies for the detection, treatment, and prevention of disease. Microdispensing and, in particular, Drop-on-Demand (DoD) technology, is an optimum technology to employ in this avenue because it allows for the delivery of customizable drug architecture due to its innovative and modular design. DoD enables customization for use in personalized medicine because it is based upon a building block methodology where the dosage and the drug delivery system is adapted by determining key attributes and combining the Active Pharmaceutical Ingredient (API) and polymer in a block matrix system. The goal of this research is to examine the feasibility of the utilization of Drop-on-Demand (DoD) technology to manufacture drugs that enable flexible dosing, poly-pharmacy, and multi-drug design dosage forms. Applied to transdermal drug delivery, we wish to design Transdermal Drug Delivery Systems (TDDS) in an innovative and systematic approach. We propose to (1) print multi drug dosage forms, (2) decrease the amount of layers currently used in the traditional system, and (3) create new dosage forms by printing the API, skin enhancers, additives, and adhesive components onto the same film with distinct patterns and configurations to achieve the desired dissolution results. |
